Search Results - donna+huryn

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Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies

HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential.

Published: 7/1/2026
Inventor(s):
Donna Huryn, Neil Hukriede, Caroline Consoli
Keywords(s):
Drug Target, Nephrology and Urology, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Novel Inhibitors of Ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.

Published: 8/1/2025
Inventor(s):
Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s):
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics

Up-regulators of utrophin expression for the treatment of muscular dystrophy

Small molecules targeting utrophin mRNA untranslated regions overcome post-transcriptional repression

Published: 8/1/2025
Inventor(s):
Tejvir Khurana, Donna Huryn
Keywords(s):
Drug Target, Genetic Disorders
Category(s):
Technology Classifications > Therapeutics

A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds

Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design

Published: 12/12/2025
Inventor(s):
Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):
 
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials