Bimane-based fluorescent probes with turn-on fluorescence in the presence of α-synuclein, a known hallmark of Altzeimer’s and Parkinson’s diseases.
Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies
N-Terminal protein modification using adenosine substrates and aminoacyl transferase
Fluorescently labeled α-synuclein to examine destabilization of synuclein fibrils by small molecules and therapeutics for neurodegenerative diseases
Natural bioactive peptides and hormones with thioamide substitutions at cleavage sites for improved pharmacokinetics