Search Results - e. james petersson

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One step N-terminal tagging of endogenous proteins for therapeutic delivery, diagnostics, and in vivo imaging

N-Terminal protein modification using adenosine substrates and aminoacyl transferase Problem: The conjugation of synthetic molecules to the termini of proteins with minimal effects on protein folding and function is an active area of biochemical research. Previous N-terminal protein modification methods suffer from side reaction products, incomplete...

Published: 3/19/2020 | Inventor(s): E. James Petersson, Alan Saghatelian

Keywords(s):

Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Diagnostics, Therapeutics & Vaccines

Non-perturbative, site-specific labeling of α-synuclein for studying amyloid disease and screening therapeutics

Fluorescently labeled α-synuclein to examine destabilization of synuclein fibrils by small molecules and therapeutics for neurodegenerative diseases Problem: Misfolding of the neuronal protein α-synuclein triggers oligomerization and the formation of amyloid fibrils that are the pathological hallmarks of Parkinson’s disease....

Published: 2/6/2020 | Inventor(s): E. James Petersson

Keywords(s):

Category(s): Chemical Processes and Synthesis, Diagnostics, Imaging, Research Tools & Reagents, Therapeutics & Vaccines

Thioamide-modified peptides for stabilized therapeutics and drug development

attractive lead pharmaceutical compounds, but peptides are subjected to rapid proteolysis in vivo. The majority of the time spent in peptide biologic drug development seeks to reduce this protein degradation, while maintaining activity. Solution: Researchers in the Petersson lab have developed a straightforward strategy to modify bioactive peptides...

Published: 12/4/2019 | Inventor(s): E. James Petersson

Keywords(s):

Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines, Materials

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