Innovation at Penn
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Search Results - emily schutsky
Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA
Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity. Problem: Epigenetic modifications to DNA, such as cytosine methylation, play critical roles in modulating gene expression without changing coding sequences. Changes or editing...
Monica Yun Liu
Research Tools & Reagents
Therapeutics & Vaccines
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