Available Technologies

Browse Penn-owned technologies available for licensing.


Search Results - george coukos

2 Results Sort By:
Universal cancer vaccine targeting tumor vasculature
A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis Technology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth....
Published: 3/16/2020   |   Inventor(s): George Coukos
Keywords(s): Oncology, Vaccine
Category(s): Therapeutics & Vaccines
Enhancing the efficacy of tumor immunotherapy by targeting Endothelin Receptor B
Antagonism of Endothelin Receptor B (ETRB) increases intratumoral T cell homing to tumors and enables tumor response to otherwise ineffective immunotherapy Problem: In spite of generating a tangible antitumor cellular immune response in peripheral blood, tumor vaccines have proven largely ineffective for treatment of solid tumors. The success...
Published: 5/29/2019   |   Inventor(s): George Coukos
Category(s): Therapeutics & Vaccines