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Universal cancer vaccine targeting tumor vasculature

A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesisTechnology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth. TEM1...

Published: 3/16/2020

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Enhancing the efficacy of tumor immunotherapy by targeting Endothelin Receptor B

Antagonism of Endothelin Receptor B (ETRB) increases intratumoral T cell homing to tumors and enables tumor response to otherwise ineffective immunotherapy Problem: In spite of generating a tangible antitumor cellular immune response in peripheral blood, tumor vaccines have proven largely ineffective for treatment of solid tumors. The success of...

Published: 5/29/2019

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