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Search Results - ivan+dmochowski

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Tri-functionalized cryptophane biosensors for biomolecular imaging and MRI diagnostics

Cryptophanes with high xenon affinity enable ultrasensitive detection of analytes in solution using Xe-129 NMR/MRITechnology Overview: The Dmochowski Lab has developed biosensors comprised of tri-functionalized cryptophane with high affinity for hyperpolarized 129Xe. These biosensors can be designed to detect molecular markers associated with cancer...

Published: 3/9/2020

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Photo-modulation of gene expression and RNA hydrolysis through photoactivatable oligonucleotide constructs

Light-activated DNA hairpin to control RNA digestion in gene silencing with mRNA-antisense complexesTechnology Overview: Gene silencing can be achieved by targeting messenger RNA (mRNA) during the transcription process. Antisense oligodeoxynucleotides can be designed to bind to a complementary mRNA sequence, where formation of the DNA-mRNA duplex recruits...

Published: 3/6/2020

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A genetically encoded β-lactamase reporter for ultrasensitive 129Xe NMR and MRI in mammalian cells

Hyperpolarized xenon chemical exchange saturation transfer (CEST) contrast agent for molecular imaging Problem: While genetically encoded optical reporters have enabled biomolecular imaging, the strong scattering of light by tissue is problematic. Optical reporters are limited to examining single cells and transparent model organisms. Alternate non-invasive...

Published: 2/5/2020

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Ruthenium photolinkers for manipulating molecular structure and function in materials science and biology

New paradigm for caging and photoreleasing polymeric systems with visible light responsive ruthenium photolinkers.Problem: Photochemical methods can manipulate and regulate molecular structure, function, and localization. Site-specifically incorporating a photolabile moiety within an oligonucleotide has remained a synthetic challenge. Moreover, methods...

Published: 1/27/2020

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Photolinker to cage biological molecules

Turn Genes “On” or “Off” with Light Technology Overview: Dmochowski lab has designed a Ruthenium-based compound, RuBEP, that is a synthetically versatile photolinker. The photolinker can be tuned to be activated at a large range of visible and near-IR wavelengths, allowing for better tissue penetration and reducing toxicity...

Published: 1/27/2020

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129Xe biosensors for molecular imaging in lungs and brain and potential early detection of breast cancer

Cell-compatible cryptophanes and functionalized 129Xe contrast agents for in vivo highly sensitive NMR and MRI measurements of cancer cellsProblem: Current breast cancer screening strategies rely on identifying morphological changes in tissue. There is not a single biomarker to identify early breast cancer, complicating biochemical, and genomic diagnostic...

Published: 11/27/2018

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