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Gene therapy for achromatopsia

Problem: There currently is no cure for Achromatopsia which affects up to 1: 50,000 patients in the US. Solution: Dr. Jean Bennett, MD, PhD, Kirby Professor of Ophthalmology at the University of Pennsylvania’s Perelman School of Medicine, one of the first investigators to develop a gene therapy for a rare inherited form of retinal blindness...

Published: 4/1/2020

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Virtual reality for low vision patients

Problem: Low vision is a significant public health problem affecting more than 3.5 million people in the US alone compromising an individuals’ sense of independence, ability to carry out daily life activities, and safety. Without retinal input, the downstream visual pathways also deteriorate. Thus, enhancement of the remaining visual function...

Published: 4/1/2020

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Enhanced gene transfer for retinal therapies

Technology Overview: While Adeno-Associated Viruses (AAVs) shows great promise in gene therapy applications for the treatment of inherited and acquired retinal diseases, a significant challenge to date has been the limitation of AAV vectors to transduce non-permissive retinal cells and to express in a single cell type. The inventors have generated...

Published: 3/20/2020

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