Search Results - john+trojanowski

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Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders.

Published: 6/28/2024

Inventor(s):

Kurt Brunden, Carlo Ballatore, Amos Smith, Virginia Lee, John Trojanowski

Keywords(s):

Aging, Neurodegenerative Diseases, Neurology, Small Molecule

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Therapeutic Antibodies Against Pathological Tau Proteins for the Treatment of Alzheimer’s Disease (AD)

Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD.

Published: 6/28/2024

Inventor(s):

Garrett Gibbons, Virginia Lee, Dawn Riddle, John Trojanowski

Keywords(s):

Antibody, Neurodegenerative Diseases

Category(s):

Technology Classifications > Therapeutics

A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds

Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design

Published: 10/16/2023

Inventor(s):

Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials