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Search Results - john trojanowski

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Therapeutic antibodies against pathological tau proteins for the treatment of Alzheimer’s Disease (AD)
Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD. Problem: More than 5 million Americans are living with Alzheimer’s disease...
Published: 5/15/2020   |   Inventor(s): Garrett Gibbons, Virginia Lee, Dawn Riddle, John Trojanowski
Category(s): Therapeutics & Vaccines
A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds
Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design Problem: Isosteric replacement of a specific group of atoms with a moiety with similar physicochemical properties is a strategy employed by medicinal chemists to improve the properties of biologically active compounds. For example, carboxylic...
Published: 3/19/2020   |   Inventor(s): Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Category(s): Chemical Processes and Synthesis, Materials, Therapeutics & Vaccines