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Search Results - michael mauk

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A portable, real-time enzymatic amplification reactor with dry storage of reagents
Point-of-care diagnostic system for nucleic acid-based analysis Technology Overview: The Bau Lab has developed a pre-loaded analysis module with reagents stored within a barrier material capable of liberating the reagents at a desired time upon exposure to activation conditions. Reagents are first prepared in dried form and encapsulated with a...
Published: 3/10/2020   |   Inventor(s): Haim Bau, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem: Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic...
Published: 2/7/2020   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Hardware & Circuits & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Nuclemeter: A yardstick for quantifying nucleic acids undergoing enzymatic amplification
or drug therapy efficacy, and identify the emergence of drug-resistant strains, particularly HIV. While real-time nucleic acid amplification and quantification methods, such as PCR, have revolutionized modern genetics and diagnostics, expensive specialized instrumentation and extensive sample preparation are needed, along with continuous monitoring...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): Nanotechnology
Category(s): Diagnostics, Research Tools & Reagents
High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics
Membrane-based, sedimentation-assisted plasma separator Problem: High sensitivity, point-of-care clinical tests, such as HIV viral load, require large volumes of plasma extracted from whole blood. Centrifugation is widely used for separating plasma, but it is not always accessible in resource-poor settings. Current microfluidic systems require...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices
Rapid plasma separator for point-of-care diagnostics and viral load detection that does not require electrical power
lways accessible and can be a limiting factor for point-of-care testing. Current microfluidic systems require extensive blood dilution that adversely affects the limit of detection, which is critical in high sensitivity tests such as viral load detection. Solution: Using size exclusion-based filtration and gravitational sedimentation, researchers...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices