Engineered Fanzor2 (Fz2) nucleases with enhanced genome editing activity in mammalian cells and demonstrated genome editing in mice.
A high throughput, model-guided tool that prioritizes candidate amino acid substitutions for protein optimization under sparse data conditions.
Machine learning framework enables neural decoding across previously unseen subjects without target-specific fine-tuning or retraining.
A stereomimicry method replaces stable chiral atoms with stereodynamic atoms to generate and evaluate drug candidate derivatives, including Glyx-13 analogs.
Automated fluorescence and optical density measurements with simultaneous optogenetics stimulation in 96-well microwell plates.
Enhancing dendrimer synthesis efficiency with pseudosymmetrization of polylysines.
Conjugating anti-T cell targeting domains onto anti-tumor autoantibodies to convert them into highly specific T cell-redirecting antibodies capable of increasing immune cell recruitment to tumor tissue.
A three-layer microfluidic device parallelizes many droplet makers while maintaining controlled fluid delivery through deep supply channels and through-hole interconnections.
With electroadhesive clutches attached, the single-chamber soft pneumatic actuator can provide local programmable stiffness modulation to achieve electronically controlled deformation.
Magnetic pore filters in microfluidic devices enable capture, release, and analysis of magnetically tagged particles, including cells and exosomes.