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Search Results - rahul kohli

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Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA
Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity. Problem: Epigenetic modifications to DNA, such as cytosine methylation, play critical roles in modulating gene expression without changing coding sequences. Changes or editing...
Published: 9/7/2018   |   Inventor(s): Rahul Kohli, Christopher Nabel, Emily Schutsky, Monica Yun Liu
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Novel Activity-Based Probes for TET Enzymatic Activity
Method and probes for detecting and quantifying epigenetic regulator TET enzymatic activity. This method can be used for high throughput screening of TET inhibitors or activators. Problem: Ten eleven translocation (TET) enzymes are important epigenetic regulators. TETs catalyze the step-wise oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine...
Published: 6/1/2018   |   Inventor(s): Rahul Kohli
Keywords(s):  
Category(s): Research Tools & Reagents