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Targeted, efficient, and safe intracellular drug delivery via nanocarriers
Cytosolic drug delivery using DNA-based nanocarriers coated with cell-targeted antibodies. Problem: The ability to deliver drugs intracellularly is critical for the treatment of diseases caused by aberrant processes within the cell. However, current drug delivery methods are ineffective at reaching the cell interior beyond the membranes of the endocytic...
Published: 5/20/2020   |   Inventor(s): Vladimir Muzykantov, Silvia Muro-Galindo
Keywords(s): Drug Delivery
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo.Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant progress...
Published: 5/4/2020   |   Inventor(s): Michael Mitchell, Rui Zhang, Roman Spektor
Keywords(s): Bioengineering, COVID-19
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines
Site-specific bioconjugation of native immunoglobulins
Method for covalent cross-linking of antibodies to surfaces for immunoassays and targeted drug delivery Technology Overview: The Tsourkas Lab has designed a facile method for the site-specific bioconjugation of native immunoglobulins (IgGs). The researchers have developed novel photoreactive Protein Z variants that allow for the introduction of...
Published: 3/20/2020   |   Inventor(s): Andrew Tsourkas
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines, Imaging
Single step protein purification and site-specific bioconjugation
Sortase-mediated expressed protein ligation and bioconjugation for molecular imaging and targeted therapeutics Technology Overview: The Tsourkas Lab has developed a novel conjugation technique that allows any single-chain recombinant protein to be site-specifically modified at the C-terminus during protein expression and purification procedures....
Published: 3/20/2020   |   Inventor(s): Andrew Tsourkas
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Imaging
New technology for detection of proton therapy beams
Technology Overview: This technology provides a novel proton beam profiling technology with excellent spatial and temporal resolution. Proton radiation therapy is becoming widely adopted for cancer treatment due to its capability of producing maximum dosage within an extremely small area and controlled depth in the tissue. In order to controllably...
Published: 3/20/2020   |   Inventor(s): Robert Hollebeek
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Fluorinated building blocks for organic synthesis and macromolecule synthesis
Synthesis of trifluoromethylated alkylboron compounds and incorporation into small molecules and macromolecules Problem: Fluorinated macromolecules are widely utilized in industry, with the most notable example being Teflon, or perfluorotetrafluoroethylene (PTFE). Additionally, methods for incorporating CF3 into small organic molecules are not...
Published: 3/20/2020   |   Inventor(s): Gary Molander
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Materials, Research Tools & Reagents
Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials
Cross-coupling reactions without the generation of waste products Problem: Catalytic carbon-carbon bond formation based on cross-coupling reactions (CCRs) plays a central role in the production of natural products, pharmaceuticals, agrochemicals, and organic materials. Coupling reactions with organometallic reagents and organic halides facilitate...
Published: 3/20/2020   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Materials, Research Tools & Reagents, Therapeutics & Vaccines
Transcriptome-wide RNA-protein interactions
RNAase-mediated protein footprint sequencing to reveal protein binding sites on transcriptome-wide scale Technology Overview: The Gregory Lab has developed a high-throughput, ribonuclease-mediated protein sequencing approach termed Protein Interaction Profile sequencing (PIP-seq). PIP-seq identifies RNA-protein interaction sites within both unprocessed...
Published: 3/19/2020   |   Inventor(s): Brian Gregory
Keywords(s):  
Category(s): Research Tools & Reagents, IT & Communication & Networking
Drug discovery and target identification platform technology using random shRNA-expressing library
shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. Problem: ShRNA Drug Discovery: RNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene expression. shRNA-expressing...
Published: 3/19/2020   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Therapeutics & Vaccines, Research Tools & Reagents
One step N-terminal tagging of endogenous proteins for therapeutic delivery, diagnostics, and in vivo imaging
N-Terminal protein modification using adenosine substrates and aminoacyl transferase Problem: The conjugation of synthetic molecules to the termini of proteins with minimal effects on protein folding and function is an active area of biochemical research. Previous N-terminal protein modification methods suffer from side reaction products, incomplete...
Published: 3/19/2020   |   Inventor(s): E. James Petersson, Alan Saghatelian
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Diagnostics, Therapeutics & Vaccines
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