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Search Results - robert wilson

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Novel Inhibitors of Ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been suggested...
Published: 10/16/2020   |   Inventor(s): Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s): Antibody, Autoimmune, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Therapeutics & Vaccines
Drug discovery and target identification platform technology using random shRNA-expressing library
shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. Problem: ShRNA Drug Discovery: RNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene expression. shRNA-expressing...
Published: 3/19/2020   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Therapeutics & Vaccines, Research Tools & Reagents
Novel compounds for treatment for Friedreich Ataxia
New compounds identified through high throughput screening which improve mitochondrial function of Friedreich ataxia cells. Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy....
Published: 3/16/2020   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases, Orphan Disease
Category(s): Therapeutics & Vaccines
Use of MAPK pathway inhibitors for the treatment of Friedreich Ataxia
A novel treatment for rare disease Friedreich ataxia using p38 or MK2 kinase inhibitors Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy. FA is the most prevalent inherited...
Published: 1/31/2020   |   Inventor(s): Robert Wilson
Keywords(s): Orphan Disease
Category(s): Therapeutics & Vaccines