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Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Published: 10/16/2020

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Drug discovery and target identification platform technology using random shRNA-expressing library

shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. Problem: ShRNA Drug Discovery: RNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene expression. shRNA-expressing...

Published: 3/19/2020

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Novel compounds for treatment for Friedreich Ataxia

New compounds identified through high throughput screening which improve mitochondrial function of Friedreich ataxia cells.Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy....

Published: 3/16/2020

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Use of MAPK pathway inhibitors for the treatment of Friedreich Ataxia

A novel treatment for rare disease Friedreich ataxia using p38 or MK2 kinase inhibitors Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy. FA is the most prevalent inherited...

Published: 1/31/2020

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