Search Results - technology+classifications+%3e+therapeutics

An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 12/15/2025

Inventor(s):

Dennis Discher, Jason Andrechak, Lawrence Dooling

Keywords(s):

Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology

Category(s):

Technology Classifications > Therapeutics

Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025

Inventor(s):

Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding

Keywords(s):

HIV/AIDS

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025

Inventor(s):

Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert

Keywords(s):

Drug Target, HIV/AIDS, Small Molecule, Soft Materials

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Novel AKR1C3 Inhibitors in Cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium

Published: 10/30/2025

Inventor(s):

Trevor Penning, Adegoke Adeniji, Michael Byrns, Jeffrey Winkler, Barry Twenter, Lawrence Marnett, Andy Liedtke

Keywords(s):

Men's Health, Oncology, Small Molecule, Women's Health

Category(s):

Technology Classifications > Therapeutics

T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases.

Published: 11/11/2025

Inventor(s):

Ning Jenny Jiang, Shahab Chizari

Keywords(s):

Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases

Category(s):

Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Human Artificial Chromosome Generation Technology

Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more.

Published: 9/19/2025

Inventor(s):

Ben Black, Craig Gambogi, John Glass, David Brown, Gabriel Birchak

Keywords(s):

Bioengineering, Gene Editing, Gene Therapy, Genetic Disorders, Platform Technology

Category(s):

Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles

Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies.