Targeted delivery of an anti-inflammatory cytokine to prevent heart failure after myocardial infarction.
HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential.
Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity.
Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations.
Phospholipid encapsulation enables enhanced ultrasound contrast and localized delivery of therapeutic gases following hypoxic-ischemic injury.
Pervious polymersomes encapsulate antioxidant agents while allowing reactive oxygen species to enter through diblock copolymer-defined channels.
A method enabling facile synthesis and purification of RNA in a stable format that does not require cold chain distribution.
Recombinant fusion bioPROTACs are combined with cationic delivery agents and lipid formulations to enable cytosolic entry and on-demand intracellular degradation of target proteins.
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