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Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025
Inventor(s):
Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding
Keywords(s):
HIV/AIDS
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025
Inventor(s):
Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert
Keywords(s):
Drug Target, HIV/AIDS, Small Molecule, Soft Materials
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Novel AKR1C3 Inhibitors in Cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium

Published: 10/30/2025
Inventor(s):
Trevor Penning, Adegoke Adeniji, Michael Byrns, Jeffrey Winkler, Barry Twenter, Lawrence Marnett, Andy Liedtke
Keywords(s):
Men's Health, Oncology, Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases.

Published: 11/11/2025
Inventor(s):
Ning Jenny Jiang, Shahab Chizari
Keywords(s):
Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Human Artificial Chromosome Generation Technology

Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more.

Published: 9/19/2025
Inventor(s):
Ben Black, Craig Gambogi, John Glass, David Brown, Gabriel Birchak
Keywords(s):
Bioengineering, Gene Editing, Gene Therapy, Genetic Disorders, Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles

Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies.

Published: 8/28/2025
Inventor(s):
Jina Ko, Jianhua Lim
Keywords(s):
Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis

Treatment of viral induced cancers

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Published: 8/7/2025
Inventor(s):
Erle Robertson
Keywords(s):
Oncology
Category(s):
Technology Classifications > Therapeutics

Peptides For Solid Cancer Tumor Immunotherapy Treatment

Short, multivalent peptide antagonists to block macrophage immune-receptor SIRPα, promoting cancer cell phagocytosis.

Published: 9/17/2025
Inventor(s):
Dennis Discher, AbdelAziz Jalil
Keywords(s):
Cell Therapy, Immunology, Oncology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis

Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL).

Published: 9/30/2025
Inventor(s):
Huafeng Wei
Keywords(s):
Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule
Category(s):
Technology Classifications > Therapeutics

DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging

Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures.

Published: 8/5/2025
Inventor(s):
Foteini Mourkioti, Ji-Hyung Lee
Keywords(s):
Aging, Drug Target, Orthopedics, Regenerative Medicine, Small Molecule
Category(s):
Technology Classifications > Therapeutics
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