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An All-In-One “Swiss Army Knife” Tool To Edit Genes And Regulate Their Expression Without Off-Target Effects And Toxicity

A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models.

Published: 5/5/2026
Inventor(s):
Xue Sherry Gao, Tyler Daniel, Hongzhi Zeng, Qichen Yuan
Keywords(s):
Bioengineering, Cell Therapy, Gene Editing, Genetic Disorders, Neurodegenerative Diseases, Obesity Metabolic Disease and Diabetes, Oncology, Orphan Disease, Pulmonary
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Interoceptomimetics: Dietary Supplements to Enhance Exercise Motivation and Performance

Enhancing exercise performance by modulating the activity of motivation-generating brain regions via stimulation of cannabinoid (CB1) receptors of the enteric nervous system.

Published: 4/30/2026
Inventor(s):
Christoph Thaiss, John Nicholas Betley
Keywords(s):
Aging, Cardiovascular, Healthcare IT, Microbiome, Neurology, Obesity Metabolic Disease and Diabetes, Regenerative Medicine, Small Molecule
Category(s):
Technology Classifications > Food Science and Nutrition, Technology Classifications > Therapeutics

Benzofuranoindoline-Containing Fungal RiPP-Derived Anticancer Compounds

Benzofuranoindoline-containing fungal RiPP-derived compounds and analogs, plus pharmaceutical compositions, and administration methods for treating cancers, including leukemia.

Published: 4/16/2026
Inventor(s):
Xue Sherry Gao, Hans Renata, Qiuyue Nie
Keywords(s):
Oncology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture

Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss.

Published: 4/16/2026
Inventor(s):
Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s):
Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

Selective Receptor Modulators for Skin Depigmentation

Small-molecule compositions modulate non-canonical sex steroid receptors to decrease, prevent, or reverse skin pigmentation gain in mammalian subjects.

Published: 4/6/2026
Inventor(s):
Todd Ridky, Christopher Natale
Keywords(s):
Dermatology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Methods for Treating, Ameliorating, and Preventing Nephropathy/Nephritis

Method for protecting against nephropathy/nephritis through topical administration of a vitamin D3 analog, producing systemic therapeutic effects potentially beneficial in protein-losing nephropathy, lupus nephritis, diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), and genetic nephropathies.

Published: 2/20/2026
Inventor(s):
Taku Kambayashi, Yuichi Yokoyama
Keywords(s):
Immunology, Nephrology and Urology
Category(s):
Technology Classifications > Therapeutics

Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery

One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery.

Published: 2/10/2026
Inventor(s):
Michael Mitchell, Xuexiang Han, Junchao Xu
Keywords(s):
Bioengineering, Drug Delivery, Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026
Inventor(s):
Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 12/15/2025
Inventor(s):
Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s):
Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025
Inventor(s):
Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding
Keywords(s):
HIV/AIDS
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines
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