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Search Results - therapeutics & vaccines

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Targeted, efficient, and safe intracellular drug delivery via nanocarriers
Cytosolic drug delivery using DNA-based nanocarriers coated with cell-targeted antibodies. Problem: The ability to deliver drugs intracellularly is critical for the treatment of diseases caused by aberrant processes within the cell. However, current drug delivery methods are ineffective at reaching the cell interior beyond the membranes of the endocytic...
Published: 5/20/2020   |   Inventor(s): Vladimir Muzykantov, Silvia Muro-Galindo
Keywords(s): Drug Delivery
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Therapeutic antibodies against pathological tau proteins for the treatment of Alzheimer’s Disease (AD)
Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD. Problem: More than 5 million Americans are living with Alzheimer’s disease...
Published: 5/15/2020   |   Inventor(s): Garrett Gibbons, Virginia Lee, Dawn Riddle, John Trojanowski
Keywords(s):  
Category(s): Therapeutics & Vaccines
Anti-RGS12 antibody for treatment of Rheumatoid Arthritis and Osteoporosis
Problem: Rheumatoid Arthritis (RA) affects between 0.5-1% of Americans with symptoms ranging from stiffness to permanent joint damage and disability. There are no effective treatments currently available for RA patients. Solution: To fill this unmet need, the researchers Drs. Yang and Yuan have developed an antibody to block the activity of Regulator...
Published: 5/5/2020   |   Inventor(s): Shicheng Yang, Gongsheng Yuan Yuan
Keywords(s):  
Category(s): Therapeutics & Vaccines
Functional nerve guidance conduit for the rapid treatment of peripheral nerve injuries
A collagen-based nerve guidance conduit containing functional Schwann cell precursor-like cells derived from stem cells for the rapid treatment of peripheral nerve injuries. Technology Overview: A peripheral nerve injury (PNI) occurs in approximately 3% of all trauma patients. While treatment options for PNIs have improved with advances in microsurgical...
Published: 5/5/2020   |   Inventor(s): Anh Le, Qunzhou Zhang
Keywords(s):  
Category(s): Medical Devices, Therapeutics & Vaccines
Treating melanoma with CAR-T cells
gy>Technology Overview: Invasive melanoma is the most lethal and costly skin cancer with over 75,000 new cases and 10,000 deaths per year in the U.S with more than one life claimed every hour. Over the past few years, immunotherapy that target common genetic mutations has dramatically changed the landscape of melanoma treatment but some patients...
Published: 5/5/2020   |   Inventor(s): Todd Ridky
Keywords(s):  
Category(s): Therapeutics & Vaccines
Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...
Published: 5/4/2020   |   Inventor(s): Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s): Therapeutics & Vaccines
Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo.Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant progress...
Published: 5/4/2020   |   Inventor(s): Michael Mitchell, Rui Zhang, Roman Spektor
Keywords(s): Bioengineering, COVID-19
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines
Novel uses of androgen receptor inhibitors in cancer
Problem: For many cancer types, women have lower incidence and better outcomes than men. The role of sex steroid hormones, such as estrogen and testosterone, has been studied in reproductive organ cancers such as prostate and breast cancer, but not in other non-androgen (AR)-driven cancers. Recent studies have shown that testosterone promotes cancer...
Published: 4/28/2020   |   Inventor(s): Todd Ridky, Cristina Aguirre Portolés, Christopher Natale
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines
Up-regulators of utrophin expression for the treatment of muscular dystrophy
Small molecules targeting utrophin mRNA untranslated regions overcome post-transcriptional repression Problem: Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disorder that affects approximately 1 in 3500 males worldwide. DMD is caused by mutations in the DMD gene that lead to severe reduction or loss of dystrophin protein. Without appropriate...
Published: 4/28/2020   |   Inventor(s): Tejvir Khurana, Donna Huryn
Keywords(s): Drug Target, Genetic Disorders, Musculoskeletal
Category(s): Therapeutics & Vaccines
Gene therapy for achromatopsia
Problem: There currently is no cure for Achromatopsia which affects up to 1: 50,000 patients in the US. Solution: Dr. Jean Bennett, MD, PhD, Kirby Professor of Ophthalmology at the University of Pennsylvania’s Perelman School of Medicine, one of the first investigators to develop a gene therapy for a rare inherited form of retinal blindness...
Published: 4/1/2020   |   Inventor(s): Jean Bennett, Jeannette Bennicelli, Junwei Sun
Keywords(s):  
Category(s): Therapeutics & Vaccines
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