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Durable and targeted nanoparticle treatment for osteoarthritis

An osteoarthritis treatment comprised of TGFa nanoparticles that penetrate cartilage and persist in the joint.Problem: Osteoarthritis (OA), a degenerative joint disease, is the most common form of arthritis, with over 32 million adults affected in the US alone. Despite its prevalence and debilitating nature, no cure or disease-modifying treatment exists....

Published: 2/26/2021

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Histone deacetylase and DNA methyltransferase inhibitors for preventative cardiac care and ischemic injury treatment

HDAC and DNMT Inhibitors such as Trichostatin A (TSA) and 5-aza-cytidine are preventative therapies and reduce myocardial infarct volume following cardiac events Technology Overview: Every 40 seconds, someone in the United States has a heart attack. Although several therapeutic options for heart attack recovery exist, ischemic injuries are responsible...

Published: 2/3/2021

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Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...

Published: 11/5/2020

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Antibody discovery platform for CAR-T cell targeting and drug conjugation

Technology Overview: Screening platform for identification of potent and specific nanobodies for (i) directing CAR-T cells to cancer cells, (ii) drug conjugation, or (iii) tumor imaging or diagnosis. Identification of antibodies capable of mediating CAR-T killing is challenging due to several reasons. First, the antibody has to have certain affinity...

Published: 11/2/2020

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Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Published: 10/16/2020

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Novel AKR1C3 inhibitors in cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometriumTechnology Overview: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward...

Published: 9/29/2020

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Ultra-fast killing of SARS-CoV-2 and enveloped viruses with a dental irrigation solution

A mixture has been identified that can rapidly deactivate SARS-CoV-2 and similar viruses for use during dental office procedures to prevent viral transmission. Problem: During routine dental procedures, aerosolized droplets containing water, a patient’s saliva and blood, microorganisms and other debris are produced as a result of commonly used...

Published: 8/20/2020

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Targeted drug delivery using red-blood cells for transport

Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood...

Published: 6/23/2020

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Protein drugs encapsulated in plant cells as low-cost prevention and treatment of lung injury in COVID-19 patients

Use of functional recombinant ACE2 and Angiotensin-(1-7) proteins to improve the clinical course of patients with symptomatic COVID-19 infection. Problem: COVID-19 is associated with high rates of respiratory failure, cardiac injury and death. Patients suffering from COVID-19 generally present with reduced expression of angiotensin converting enzyme...

Published: 6/2/2020

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Therapeutic antibodies against pathological tau proteins for the treatment of Alzheimer’s Disease (AD)

Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD. Problem: More than 5 million Americans are living with Alzheimer’s disease...

Published: 5/15/2020

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