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Universal cancer vaccine targeting tumor vasculature
A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis Technology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth....
Published: 3/16/2020   |   Inventor(s): George Coukos
Keywords(s): Oncology, Vaccine
Category(s): Therapeutics & Vaccines
Therapeutic Vaccine for Myasthenia Gravis
Vaccine offering potential cure for rare autoimmune disorder Myasthenia Gravis. Problem: Myasthenia gravis (MG) is caused by an antibody-mediated autoimmune response to muscle nicotinic acetylcholine receptors (AChRs) of skeletal muscles that impairs neuromuscular transmission, resulting in weakness and fatigability. The prevalence in the U.S....
Published: 1/27/2020   |   Inventor(s): Jon Lindstrom
Keywords(s): Vaccine
Category(s): Therapeutics & Vaccines
Tumor mitochondria vaccine for the treatment of cancer
Problem: Progression in cancer immunotherapy has been rapid with a number of products currently available and many others in late stage clinical development. However, clinical response to immunotherapies is variable and dependent on cancer types as well as specific characteristics or genetic mutations within a patient’s individual tumor. There...
Published: 1/23/2020   |   Inventor(s): Andrea Facciabene
Keywords(s): Immunotherapy, Oncology, Vaccine
Category(s): Therapeutics & Vaccines
Broad non-typeable Haemophilus influenzae vaccine
Problem: Haemophilus influenzae (H. influenzae) colonizes in the upper respiratory tract causing a wide variety of diseases, including otitis media, conjunctivitis, sinusitis, pneumonia, and meningitis. H. influenzae strains are classified into 6 serotypes depending on antibody specificity to the bacterial capsule. There is also a genetically diverse...
Published: 7/30/2019   |   Inventor(s): Hao Shen, Brian Akerley
Keywords(s): Vaccine
Category(s): Therapeutics & Vaccines