Search Results - xuexiang+han

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Highly Efficient Approach for Developing Biocompatible and Potent Lipid Nanoparticles

Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method.

Published: 5/8/2026

Inventor(s):

Michael Mitchell, Xuexiang Han, Rohan Palanki

Keywords(s):

Bioengineering, Drug Delivery, Nanotechnology, Platform Technology

Category(s):

Technology Classifications > Therapeutics

Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery

One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery.

Published: 2/10/2026

Inventor(s):

Michael Mitchell, Xuexiang Han, Junchao Xu

Keywords(s):

Bioengineering, Drug Delivery, Platform Technology

Category(s):

Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026

Inventor(s):

Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton

Keywords(s):

Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 12/8/2025

Inventor(s):

Michael Mitchell, Xuexiang Han

Keywords(s):

Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines