Search Results - xuexiang+han

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Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 2/6/2024

Inventor(s):

Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang

Keywords(s):

Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology

Category(s):

Technology Classifications > Therapeutics

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 2/7/2024

Inventor(s):

Michael Mitchell, Xuexiang Han

Keywords(s):

Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines