Search Results - xuexiang+han

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Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery

One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery.

Published: 2/10/2026

Inventor(s):

Michael Mitchell, Xuexiang Han, Junchao Xu

Keywords(s):

Bioengineering, Drug Delivery, Platform Technology

Category(s):

Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026

Inventor(s):

Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton

Keywords(s):

Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 12/8/2025

Inventor(s):

Michael Mitchell, Xuexiang Han

Keywords(s):

Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines