Search Results - xuexiang+han

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Space Shuttle-Inspired Branched Lipid Nanoparticles As Potent mRNA Transporters

Lipid nanoparticles (LNPs) with reversibly attached branched lipid tails for the delivery of mRNA for gene therapy.

Published: 10/16/2024
Inventor(s):
Michael Mitchell, Xuexiang Han
Keywords(s):
Bioengineering, Drug Delivery, Gene Therapy, Nanotechnology, Obesity Metabolic Disease and Diabetes, Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Adjuvanted Lipid Nanoparticles (LNPs) Enhance Protective Immunity Imparted by SARS-CoV-2 mRNA Vaccine

A lipid nanoparticle formulation that elicits a strong innate immune response for improved vaccine protection

Published: 10/1/2024
Inventor(s):
Michael Mitchell, Xuexiang Han, Drew Weissman, Mohamad Alameh
Keywords(s):
Bioengineering, COVID-19, Drug Delivery, Immunology, Infectious Disease, Nanotechnology
Category(s):
Technology Classifications > Materials, Technology Classifications > Vaccines

Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 2/6/2024
Inventor(s):
Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Xuexiang Han
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines