Available Technologies

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Leader sequence to boost gene expression

Technology Overview: 

The inventors have designed a 28-codon leader tag that, when incorporated onto the 5’ end of a gene of interest, significantly improves gene expression efficiency and protein production in recombinant expression systems.  The leader sequence boosts protein production by introducing weak secondary structure into the mRNA, permitting more efficient binding near the ribosomal binding site.

Intellectual Property: 

Issued US patent:  US 12/984,251

Reference Media: 

Kudla, G., et al., Science. 2009 Apr 10;324(5924):255-8

Patent Information:


Docket # W5333

For Information, Contact:

Pamela Beatrice Director, SEAS/SAS Licensing Group
University of Pennsylvania