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The inventors have designed a 28-codon leader tag that, when incorporated onto the 5’ end of a gene of interest, significantly improves gene expression efficiency and protein production in recombinant expression systems. The leader sequence boosts protein production by introducing weak secondary structure into the mRNA, permitting more efficient binding near the ribosomal binding site.
Issued US patent: US 12/984,251
Kudla, G., et al., Science. 2009 Apr 10;324(5924):255-8
Docket # W5333