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Dr. Black and his team have discovered specific changes in structure and molecular contacts within PARP enzymes caused by PARPi. Using biochemical and biophysical methodologies the team is able to determine whether a candidate PARPi compound may represent a strong anti-cancer compound (i.e. a “trapping” compound that would be a robust cancer cell killer) or a compound that would be a strong candidate for treatment of other diseases (i.e. a “non-trapping” compound with low cellular toxicity). Using this method the team has developed a series of "trapping" and "non-trapping" PARP inhibitors (19-8790).