Available Technologies

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A drug delivery system tuned to the endogenous mechanical environment


Technology Overview:

Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels. Given the centrality of mechanical loading in normal tissue function, Drs. Mauck, Dodge, and Lee at the University of Pennsylvania developed a mechanically activated drug delivery system to stimulate regeneration and repair in mechanically loaded musculoskeletal tissues (e.g. cartilage, muscle, bone).


This technology has a wide variety of uses, such as prophylactic treatment of a joint after surgery, prevention of post-traumatic osteoarthritis, and improvement of cartilage regeneration and repair using tissue-engineered cartilage strategies.





  • Localized delivery
  • Sequential release of therapeutics over a long period of time
  • Ease of maintenance of drug concentration within a therapeutic range
  • Physiologic/self- regulating release




Stage of Development:

Proof of concept using a model microcapsule system 


Intellectual Property:

Provisional Patent Filed 


Reference Media:

  • Tu, Fuquan, and Daeyeon Lee. "Controlling the Stability and Size of Double-Emulsion-Templated Poly(lactic--glycolic) Acid Microcapsules." Langmuir 28.26 (2012): 9944-952.
  • Bhavana Mohanraj et al.  “Mechano-activatable microcapsules for tunable drug delivery” Summer Biomechanics, Bioengineering, and Biotransport Conference, 2015, June 17


Desired Partnerships:



Docket #  15-7304


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Patent Information:
For Information, Contact:
Jeffrey James
Associate Director, PSOM Licensing Group
University of Pennsylvania
Robert Mauck
George Dodge
Daeyeon Lee
Drug Delivery