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Rapid, novel mouse model of gastric cancer with metastasis
University of Pennsylvania investigators developed a model of mixed type gastric cancer results from combinatorial conditional loss of the Cdh1 (E-cadherin), and p53 genes, and acquisition of expression of oncogenic Kras in gastric parietal cells. Mice exhibit significant disease related morbidity at a median of 77 days of age. Upon gross examination at necropsy 100% of mice present with enlarged, thickened, and whitened stomachs (linea plastic), epigastric lymph node metastases (100%) and mediastinal lymph node metastases (50%).
Upon microscopic evaluation the primary tumors were characterized as mixed type gastric cancer containing >25% diffuse type cells. Microscopic observation confirmed the metastatic lesions through the use of the conditional YFP reporter allele (also present in the model) and further identified lung metastases in 100% of mice and liver metastases in 20% of mice.
Sandra Ryeom Ph.D., Department of Cancer Biology
Docket # 16-7648