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Researchers at the University of Pennsylvania have discovered and characterized a novel endogenous cyclic glutathione (GSH) adduct (TOG) which represents the first member of a new class of biomarkers that can be used to quantify intracellular oxidative stress.
Oxidative stress is involved in the pathogenesis of a variety of diseases including cardiovascular disease, cancer and neurodegenerative disease. It occurs as a result of increased production of reactive oxygen species (ROS) which in turn can cause increased lipid peroxidation mediated damage to DNA and proteins. TOG could be used as a biomarker in basic research and clinical studies, and also could be used as a biomarker to measure the efficiency of various drugs which are being developed to treat asthma and cardiovascular disease.
Issued US Patent(s): 11/976,316
Zhu, P., et al. Free Radic Biol Med. 2009 Oct 1;47(7):953-61
Docket # S3993