Available Technologies

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GSH Adducts and uses thereof

Technology Overview: 

Researchers at the University of Pennsylvania have discovered and characterized a novel endogenous cyclic glutathione (GSH) adduct (TOG) which represents the first member of a new class of biomarkers that can be used to quantify intracellular oxidative stress.

Oxidative stress is involved in the pathogenesis of a variety of diseases including cardiovascular disease, cancer and neurodegenerative disease. It occurs as a result of increased production of reactive oxygen species (ROS) which in turn can cause increased lipid peroxidation mediated damage to DNA and proteins. TOG could be used as a biomarker in basic research and clinical studies, and also could be used as a biomarker to measure the efficiency of various drugs which are being developed to treat asthma and cardiovascular disease.

Intellectual Property: 

Issued US Patent(s):  11/976,316

Reference Media: 

Zhu, P., et al. Free Radic Biol Med. 2009 Oct 1;47(7):953-61

Patent Information:

Inventors:

Docket # S3993

For Information, Contact:

Robert Schenkel Director, Special Business Projects
University of Pennsylvania
215-898-9385
robh@upenn.edu

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