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However, transmission of these viruses relies heavily on highly conserved host cell mechanisms. Accordingly, therapeutic strategies targeting these host mechanisms have become an attractive and innovative approach for developing antivirals that circumvent the issue of drug resistance and that can provide broad spectrum activity.
This influx of calcium orchestrates late steps of viral assembly and budding. Indeed, pharmacologically blocking or genetically inactivating the Orai Ca2+ entry channel, significantly attenuates budding and spread of infectious Ebola, Marburg, Lassa Fever, and other related RNA viruses; highlighting the fact that this antiviral approach has broad spectrum activity against enveloped RNA virus budding.