Targeted Drug Delivery Using Red-Blood Cells for Transport

Platform technology for targeted drug delivery using red blood cells for transport. 


Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood cell. 


A platform technology for targeted drug delivery to target organs while reducing off target drug effects. This platform technology can be used with a variety of small molecule drugs required for treating organ sites without modifying the structure of the red blood cell. 

Technology Overview: 

Liposomes have been engineered to display antibodies that target red-blood cells and specific organ-sites, allowing for dual targeting. The liposomes can be loaded with a variety of small molecule drugs. Binding the liposome loaded with the drug molecule to red blood cells allows for leveraging red blood cells as drug shuttles and carriers.


  • 2x greater drug delivery to the targeted organ as compared to passive red blood cell binding
  • Control of nanocarrier binding to red blood cell to reduce variability
  • Utilization with a broad range of nanocarriers
  • Increased plasma half-life of nanocarriers

Stage of Development: 

  • In vivo proof of concept

Intellectual Property: 

Reference Media: 

Desired Partnerships: 

  • License
  • Co-development
Patent Information:


Jessica Casciano

Assistant Director, PSOM Licensing Group
University of Pennsylvania
(215) 573-5414



Docket # 20-9162