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Search Results - george coukos

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Enhancing the Efficacy of Tumor Immunotherapy by Targeting Endothelin Receptor B
Antagonism of Endothelin Receptor B (ETRB) increases intratumoral T cell homing to tumors and enables tumor response to otherwise ineffective immunotherapy TechnologyProblem: In spite of generating a tangible antitumor cellular immune response in peripheral blood, tumor vaccines have proven largely ineffective for treatment of solid tumors. Thesucc...
Published: 5/29/2019   |   Inventor(s): George Coukos
Keywords(s):  
Category(s): Therapeutics & Vaccines
Universal cancer vaccine targeting tumor vasculature
Brief DescriptionA DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesisTechnology OverviewImmunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tu...
Published: 8/31/2015   |   Inventor(s): George Coukos
Keywords(s): Cancer, Vaccine
Category(s): Therapeutics & Vaccines