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A method to identify modulators for regulatory T cell functions



Docket #  T4518 



Technology Overview

Maintenance of tolerance to self-antigens is essential for the prevention of autoimmunity. This process is known to involve specific regulatory T cells (Treg) and the expression of the forkhead family transcription factor, FOXP3. FOXP3 is a “sufficient” regulator of the development and function of peripheral Treg cells, but the molecular mechanisms of FOXP3-mediated immunological regulation are still poorly understood.


Mutations in the forkhead domain of FOXP3 are found in the fatal recessive disorder, “X-linked autoimmunity and allergic dysregulation syndrome” (XLAAD) or “Immunodysregulation, polyendocrinopathy and enteropathy, X-linked syndrome” (IPEX). These individuals fail to develop CD4+CD25+ T cells and experience varied symptoms from insulin-dependent diabetes to anemia, as well as massive T cell infiltration of the skin and gastrointestinal tract.


The present invention features methods of identifying immune response modulators by measuring various aspects of FOXP3 function.



• An approach to identify novel inhibitors for diseases that regulatory T cells are involved.

• Specific to FOXP3 functions that are relevant to the binding to HDAC and HAT.




Mark Greene, M.D., Ph.D., F.R.C.P.  

State of Development

Elucidation of mechanism of action in an in vitro model system of human cells from with XLAAD/IPEX patients. 

Intellectual Property

US Patent 8,846,308.


Reference Media

Li, B et al.  International Immunology 19.7 (2007): 825-35.


Desired partnerships

• License


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Patent Information:
For Information, Contact:
Viviane Martin
Director, PSOM Licensing Group
University of Pennsylvania
Mark Greene