Available Technologies

Browse Penn-owned technologies available for licensing.

HOME SEARCH RSS FEED

A method to identify modulators for regulatory T cell functions

Description:

 

Docket #  T4518 

 

 

Technology Overview

Maintenance of tolerance to self-antigens is essential for the prevention of autoimmunity. This process is known to involve specific regulatory T cells (Treg) and the expression of the forkhead family transcription factor, FOXP3. FOXP3 is a “sufficient” regulator of the development and function of peripheral Treg cells, but the molecular mechanisms of FOXP3-mediated immunological regulation are still poorly understood.

 

Mutations in the forkhead domain of FOXP3 are found in the fatal recessive disorder, “X-linked autoimmunity and allergic dysregulation syndrome” (XLAAD) or “Immunodysregulation, polyendocrinopathy and enteropathy, X-linked syndrome” (IPEX). These individuals fail to develop CD4+CD25+ T cells and experience varied symptoms from insulin-dependent diabetes to anemia, as well as massive T cell infiltration of the skin and gastrointestinal tract.

 

The present invention features methods of identifying immune response modulators by measuring various aspects of FOXP3 function.

 

Advantages

• An approach to identify novel inhibitors for diseases that regulatory T cells are involved.

• Specific to FOXP3 functions that are relevant to the binding to HDAC and HAT.

 

 

Inventor

Mark Greene, M.D., Ph.D., F.R.C.P.  

State of Development

Elucidation of mechanism of action in an in vitro model system of human cells from with XLAAD/IPEX patients. 

Intellectual Property

US Patent 8,846,308.

 

Reference Media

Li, B et al.  International Immunology 19.7 (2007): 825-35.

 

Desired partnerships

• License

 

Download PDF

 


Patent Information:
For Information, Contact:
Viviane Martin
Director, PSOM Licensing Group
University of Pennsylvania
215-746-4275
martinv@upenn.edu
Inventors:
Mark Greene
Keywords:
Autoimmune
Biotechnology