Browse Penn-owned technologies available for licensing.
FOXP3 is a “sufficient” regulator of the development and function of peripheral Treg cells, but the molecular mechanisms of FOXP3-mediated immunological regulation are still poorly understood.
Mutations in the forkhead domain of FOXP3 are found in the fatal recessive disorder, “X-linked autoimmunity and allergic dysregulation syndrome” (XLAAD) or “Immunodysregulation, polyendocrinopathy and enteropathy, X-linked syndrome” (IPEX). These individuals fail to develop CD4+CD25+ T cells and experience varied symptoms from insulin-dependent diabetes to anemia, as well as massive T cell infiltration of the skin and gastrointestinal tract.
The present invention features methods of identifying immune response modulators by measuring various aspects of FOXP3 function.