Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Technology Overview: While antibody therapeutics have proven to be successful in recent years, they are not without drawbacks. The large size of antibodies can prevent their effective use against certain cancers, as well as prevent them from crossing the blood-brain barrier. Additionally, many antibodies require post-translational modifications and...

The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...

CXCR6 is a chemokine receptor expressed by leukocytes and other cells, and is believed to play a role in cancer metastasis, gut mucosal integrity, autoimmunity, diabetes and other inflammatory disorders. It is also used by SIV as a co-receptor for target cell entry. Technology Overview: Current commercially available monoclonal antibodies that react...

Technology Overview: Roughly 12 million patients are exposed to heparin annually and up to 1% of these patients will develop heparin-induced thrombocytopenia/thrombosis (HIT), a life-threatening complication where patients make antibodies that bind to the heparin/PF4 complex, resulting in thrombosis and thrombocytopenia. The Greene lab has identified...

mono (IgGsb) Clone: 4E1 Applications: ELISA, flow cytometry, IHC, IP, WB Species Reactivity: human Alternative Names: West nile virus envelope protein Immunogen: DNA plasmid encoding WNV prM and E (full length), and an innoculation with soluble E protein Relevant Publications: ...

mono (IgG1) Clone: 8B10 Applications: ELISA, IP, IHC, neutrralization assay, WB Species Reactivity: human Alternative Names: West nile virus envelope protein Immunogen: DNA plasmid encoding WNV prM and E (full length), and an innoculation with inactivated virus (8B10)...

mono (IgG2a) Clone: 17D7 Applications: ELISA, IHC, IP, WB Species Reactivity: human Alternative Names: West nile virus envelope protein Immunogen: DNA plasmid encoding WNV prM and E (full length), with booster of formalin inactivated virus Relevant Publications: ...

Monoclonal Clone: 3F1 Applications: ICC, IP, WB Species Reactivity: Human Alternative Names: DEAD box protein 48 Immunogen: Mouse anti-eIF4A3 monoclonal antibody 3F1 was prepared by immunizing BALB/c mice with full-length recombinant GSTeIF4A3. Relevant Publications: ...

Monoclonal (IgG3) Clone: 3H14 Applications: ELISA, WB Species Reactivity: Human Alternative Names: KPNB1 Immunogen: Recombinant protein corresponding to human Importin beta-1. Relevant Publications: [ELISA, WB] - data available Tech-ID: Q3267