Search Results - antibody

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Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 2/27/2025
Inventor(s):
Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s):
Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Neuroprotection in TBI/Concussion via Dietary Supplement

A dietary supplement that protects brain cells from the effects of TBI and concussion  

Published: 6/24/2024
Inventor(s):
Daniel Kacy Cullen, Carolyn Keating, Kevin Browne
Keywords(s):
Antibody, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Therapeutics

Platform Technology for Cell Engineering and Cell Programming

A platform technology utilizing synthetic organelles to modulate cell cycle, cell behavior, and stemness/differentiation status which could be used for cell engineering, cell therapy etc.

Published: 1/10/2024
Inventor(s):
Matthew Good, Mikael Garabedia
Keywords(s):
Antibody, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Research Tools & Reagents

Coated Metallic Nanoclusters without Carrier Molecule

Nanocluster agents that enable imaging through cyanine dyes and/or photosensitizers without the need for additional carrier molecules.

Published: 4/25/2025
Inventor(s):
Andrew Tsourkas, Jayesh Thawani, Ahmad Amirshaghaghi, Lesan Yan, Zhiliang Cheng
Keywords(s):
Antibody, Cell Therapy
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging, Technology Classifications > Materials

Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

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Published: 10/16/2023
Inventor(s):
Xianxin Hua
Keywords(s):
Antibody, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Imaging

Antibody discovery platform for CAR-T cell targeting and drug conjugation

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Published: 1/5/2024
Inventor(s):
Xianxin Hua
Keywords(s):
Antibody, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Imaging

Therapeutic Antibodies Against Pathological Tau Proteins for the Treatment of Alzheimer’s Disease (AD)

Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD.

Published: 6/28/2024
Inventor(s):
Garrett Gibbons, Virginia Lee, Dawn Riddle, John Trojanowski
Keywords(s):
Antibody, Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics

Antibodies for targeting CAR-T cells to neuroendocrine tumors

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Published: 10/16/2023
Inventor(s):
Xianxin Hua
Keywords(s):
Antibody, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Imaging

Antibody-like therapeutic platform with effector function

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Published: 2/12/2024
Inventor(s):
Mark Greene
Keywords(s):
Antibody
Category(s):
Technology Classifications > Therapeutics

Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells

The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing mesothelin. 

Published: 2/20/2025
Inventor(s):
Daniel Powell
Keywords(s):
Antibody, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Therapeutics
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