Search Results - antibody

Available Technologies

Browse Penn-owned technologies available for licensing.

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Antibody-like therapeutic platform with effector function

Technology Overview: While antibody therapeutics have proven to be successful in recent years, they are not without drawbacks. The large size of antibodies can prevent their effective use against certain cancers, as well as prevent them from crossing the blood-brain barrier. Additionally, many antibodies require post-translational modifications and...

Published: 3/18/2020 | Inventor(s): Mark Greene

Keywords(s): Antibody, Therapeutics

Category(s): Therapeutics & Vaccines

Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells

The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...

Published: 1/29/2020 | Inventor(s): Daniel Powell

Keywords(s): Antibody, Autoimmune, Cell Therapy, Immunology, Immunoncology, Oncology

Category(s): Therapeutics & Vaccines

Monoclonal antibody to CXCR6

CXCR6 is a chemokine receptor expressed by leukocytes and other cells, and is believed to play a role in cancer metastasis, gut mucosal integrity, autoimmunity, diabetes and other inflammatory disorders. It is also used by SIV as a co-receptor for target cell entry. Technology Overview: Current commercially available monoclonal antibodies that...

Published: 1/28/2020 | Inventor(s): Ronald Collman

Keywords(s): Antibody, Autoimmune, Oncology

Category(s): Research Tools & Reagents

Therapy for heparin-induced thrombocytopenia (HIT) targeting the epitope structure of the disease –inducing antibody

Technology Overview: Roughly 12 million patients are exposed to heparin annually and up to 1% of these patients will develop heparin-induced thrombocytopenia/thrombosis (HIT), a life-threatening complication where patients make antibodies that bind to the heparin/PF4 complex, resulting in thrombosis and thrombocytopenia. The Greene lab has identified...

Published: 1/23/2020 | Inventor(s): Mark Greene

Keywords(s): Antibody

Category(s): Therapeutics & Vaccines, Diagnostics, Research Tools & Reagents

anti-WNV E (mouse)

mono (IgGsb) Clone: 4E1 Applications: ELISA, flow cytometry, IHC, IP, WB Species Reactivity: human Alternative Names: West nile virus envelope protein Immunogen: DNA plasmid encoding WNV prM and E (full length), and an innoculation with soluble E protein Relevant Publications: ...