Search Results - car+t-cell+enhancing+technology

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Compositions and methods for enhancing the anti-tumor activity of CAR T cells by co-expression of CH25H

Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers. 

Published: 1/23/2024
Inventor(s):
Serge Fuchs, Noreen McBrearty, Zhen Lu
Keywords(s):
Bioengineering, CAR T-cell Enhancing Technology, Cell Therapy, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

CD137 enrichment of tumor-specific tumor-infiltrating lymphocytes (TILs)

A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies.

Published: 4/2/2024
Inventor(s):
Daniel Powell
Keywords(s):
CAR T-cell Enhancing Technology, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Single viral vector for expression of both CAR/TCR and immune modulators for cancer immunotherapy

A single lentiviral vector system as an expression platform for constitutive immune receptor expression and inducible antigen-dependent immunomodulatory molecule expression in primary immune cells for enhanced immunotherapy efficacy

Published: 1/23/2024
Inventor(s):
Daniel Powell, Anze Smole, Avery Posey
Keywords(s):
CAR T-cell Enhancing Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics