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Search Results - changchun liu

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A disposable self-heating cartridge for point-of-care molecular diagnostics
A water-activated, self-heating, instrument-free microfluidic diagnostic cartridge Problem: Many molecular diagnostic devices require elevated temperatures to carry out biochemical reactions, such as those needed for nucleic acid amplification, including loop-mediated isothermal amplification (LAMP). The temperature is typically regulated with...
Published: 3/19/2020   |   Inventor(s): Changchun Liu, Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A membrane-based, high-efficiency microfluidic debubbler for point-of-care devices
Problem: Microfluidic devices often suffer from unwanted bubbles inside a channel, resulting in obstructed fluidic paths, lower reaction efficiency, detection distortion, and interference with bead array-based assays. Existing active debubblers that use pneumatics or vacuum to trap and dissipate bubbles require an external vacuum source, preventing...
Published: 3/19/2020   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A pouch-based cassette for bio-detection with timer-based actuator
Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assays Technology Overview: The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system. Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms,...
Published: 3/6/2020   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices
Method and microfluidic chip for two-stage multiplexed isothermal enzymatic amplification
On-chip two-step nucleic acid amplification for point-of-care and clinical molecular detection of multiple diseases and co-infections Problem: Polymerase chain reaction methods (PCR) for nucleic acid amplification have revolutionized molecular diagnostics and genetics research. Nested PCR relies on two successive runs of thermal cycling and two...
Published: 2/3/2020   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes
A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and G Problem: HIV infection remains an international health crisis, where it is especially acute in sub-Saharan Africa, despite the development of antiretroviral therapy. High sensitivity, point-of-care clinical diagnostic tests for detecting...
Published: 1/28/2020   |   Inventor(s): Haim Bau, Changchun Liu, Frederic Bushman
Keywords(s):  
Category(s): Diagnostics, Research Tools & Reagents, Medical Devices
Nuclemeter: A yardstick for quantifying nucleic acids undergoing enzymatic amplification
or drug therapy efficacy, and identify the emergence of drug-resistant strains, particularly HIV. While real-time nucleic acid amplification and quantification methods, such as PCR, have revolutionized modern genetics and diagnostics, expensive specialized instrumentation and extensive sample preparation are needed, along with continuous monitoring...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): Nanotechnology
Category(s): Diagnostics, Research Tools & Reagents
High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics
Membrane-based, sedimentation-assisted plasma separator Problem: High sensitivity, point-of-care clinical tests, such as HIV viral load, require large volumes of plasma extracted from whole blood. Centrifugation is widely used for separating plasma, but it is not always accessible in resource-poor settings. Current microfluidic systems require...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices
Rapid plasma separator for point-of-care diagnostics and viral load detection that does not require electrical power
lways accessible and can be a limiting factor for point-of-care testing. Current microfluidic systems require extensive blood dilution that adversely affects the limit of detection, which is critical in high sensitivity tests such as viral load detection. Solution: Using size exclusion-based filtration and gravitational sedimentation, researchers...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices