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A disposable self-heating cartridge for point-of-care molecular diagnostics

A water-activated, self-heating, instrument-free microfluidic diagnostic cartridge Problem: Many molecular diagnostic devices require elevated temperatures to carry out biochemical reactions, such as those needed for nucleic acid amplification, including loop-mediated isothermal amplification (LAMP). The temperature is typically regulated with external...

Published: 3/19/2020

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A membrane-based, high-efficiency microfluidic debubbler for point-of-care devices

Problem: Microfluidic devices often suffer from unwanted bubbles inside a channel, resulting in obstructed fluidic paths, lower reaction efficiency, detection distortion, and interference with bead array-based assays. Existing active debubblers that use pneumatics or vacuum to trap and dissipate bubbles require an external vacuum source, preventing...

Published: 3/19/2020

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A pouch-based cassette for bio-detection with timer-based actuator

Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assaysTechnology Overview: The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system. Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms,...

Published: 3/6/2020

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Method and microfluidic chip for two-stage multiplexed isothermal enzymatic amplification

On-chip two-step nucleic acid amplification for point-of-care and clinical molecular detection of multiple diseases and co-infectionsProblem: Polymerase chain reaction methods (PCR) for nucleic acid amplification have revolutionized molecular diagnostics and genetics research. Nested PCR relies on two successive runs of thermal cycling and two sets...

Published: 2/3/2020

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A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes

A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and G Problem: HIV infection remains an international health crisis, where it is especially acute in sub-Saharan Africa, despite the development of antiretroviral therapy. High sensitivity, point-of-care clinical diagnostic tests for detecting...

Published: 1/28/2020

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Nuclemeter: A yardstick for quantifying nucleic acids undergoing enzymatic amplification

Point-of-care, reaction-diffusion column-based, non-instrumented device for real-time visual measurement of viral load in resource-limited settings, in the clinic, and at home Problem: Quantification of viral load in patients is needed to assess disease progression, monitor drug therapy efficacy, and identify the emergence of drug-resistant strains,...

Published: 1/23/2020

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High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics

Membrane-based, sedimentation-assisted plasma separator Problem: High sensitivity, point-of-care clinical tests, such as HIV viral load, require large volumes of plasma extracted from whole blood. Centrifugation is widely used for separating plasma, but it is not always accessible in resource-poor settings. Current microfluidic systems require...

Published: 1/23/2020

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Rapid plasma separator for point-of-care diagnostics and viral load detection that does not require electrical power

Membrane-based, sedimentation-assisted plasma separator from whole blood for clinical tests Problem: High sensitivity, point-of-care clinical tests, such as HIV load, require large volumes of plasma. Centrifugation is widely used for separating plasma from whole blood, but it is not always accessible and can be a limiting factor for point-of-care...

Published: 1/23/2020

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