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A pouch-based cassette for bio-detection with timer-based actuator

Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assays

Technology Overview: 

The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system.  Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms, capping chambers storing reagents and/or wash solutions.  In an alternative embodiment of the device, a pouching actuator is controlled by a spring-driven mechanical timer.  The actuator consists of a timing dial, actuation disc, ball-holding plate, cassette socket and platform, and timer spring box.  Delivery sequence is determined by the number and relative position of balls and protrusions on the holding plate and actuation disc, respectively.

Advantages: 

  • Portable, handheld platform
  • Fully integrated, automatic sample preparation, target purification, and amplification
  • Rapid analysis time
  • Low cost
  • Reusable or disposable timer-based actuator
  • Diagnostic performance on par with existing lab-based tests

Applications: 

  • Point-of-care diagnostics
  • Lab-on-a-chip
  • Immunoassays

 

Top: Immunoassay chip with integrated actuator. Bottom: Schematic diagram of mechanically activated actuator

Stage of Development: 

Proof-of-concept prototype developed with demonstrated feasibility of molecular marker detection in oral fluid

Intellectual Property: 

Reference Media: 

Desired Partnerships: 

  • License
  • Co-development

Patent Information:

Inventors:

Haim Bau
Changchun Liu

Docket # U4838, T4403

For Information, Contact:

Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
jeanson@upenn.edu

Keywords: