Innovation at Penn
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A pouch-based cassette for bio-detection with timer-based actuator
Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assays
The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system. Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms, capping chambers storing reagents and/or wash solutions. In an alternative embodiment of the device, a pouching actuator is controlled by a spring-driven mechanical timer. The actuator consists of a timing dial, actuation disc, ball-holding plate, cassette socket and platform, and timer spring box. Delivery sequence is determined by the number and relative position of balls and protrusions on the holding plate and actuation disc, respectively.
Portable, handheld platform
Fully integrated, automatic sample preparation, target purification, and amplification
Rapid analysis time
Reusable or disposable timer-based actuator
Diagnostic performance on par with existing lab-based tests
Top: Immunoassay chip with integrated actuator. Bottom: Schematic diagram of mechanically activated actuator
Stage of Development:
Proof-of-concept prototype developed with demonstrated feasibility of molecular marker detection in oral fluid
Qiu X. et al.
Sensors and Actuators B: Chemical
, 2011, 160(1), p. 1529-1535.
Liu C. et al.
Lab on a Chip
, 2009, 9(6), p. 768-776
Docket # U4838, T4403
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