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Search Results - covid-19
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Rapid pathogen diagnostic through amplification of red blood cell-associated DNA
Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...
Published:
11/24/2020
Inventor(s):
Nilam Mangalmurti
Keywords(s):
COVID-19
,
Immunology
,
Infectious Disease
,
Inflammation
Category(s):
Diagnostics
Rapid and ultrasensitive SARS-CoV-2 antigen detection for acute
COVID-19
screening in community settings
rss.brief>A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The
COVID-19
pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time...
Published:
11/11/2020
Inventor(s):
Ping Wang
Keywords(s):
COVID-19
,
Immunology
,
Infectious Disease
,
Microfluidics
,
Pulmonary
Category(s):
Diagnostics
Low-cost rapid diagnostic for
COVID-19
A
COVID-19
diagnostic approach, utilizing a SARS-CoV-2 binding biosensor, that allows for real-time virus detection, without the need for sample processing, ultimately leading to population-level surveillance, outbreak tracking, reduced healthcare costs, improved treatment outcomes, and saved lives. Problem: SARS-CoV-2, the virus that causes COVID-19,...
Published:
11/5/2020
Inventor(s):
Cesar de la Fuente
,
Marcelo Der Torossian Torres
,
William Reis de Araujo
Keywords(s):
Bioengineering
,
COVID-19
,
Infectious Disease
Category(s):
Diagnostics
,
Digital Health
,
Hardware & Circuits & Sensors
Ultra-fast killing of SARS-CoV-2 and enveloped viruses with a dental irrigation solution
A mixture has been identified that can rapidly deactivate SARS-CoV-2 and similar viruses for use during dental office procedures to prevent viral transmission. Problem: During routine dental procedures, aerosolized droplets containing water, a patient’s saliva and blood, microorganisms and other debris are produced as a result of commonly used...
Published:
8/20/2020
Inventor(s):
Robert Ricciardi
,
Hyun Koo
,
Mark Wolff
Keywords(s):
COVID-19
,
Dentistry
,
Infectious Disease
,
Surgery
Category(s):
Materials
,
Therapeutics & Vaccines
Targeted drug delivery using red-blood cells for transport
Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood...
Published:
6/23/2020
Inventor(s):
Laura Ferguson
,
Elizabeth Hood
,
Carlos Villa
,
Jacob Brenner
,
Vladimir Muzykantov
Keywords(s):
Cardiovascular
,
COVID-19
,
Drug Delivery
,
Nanotechnology
,
Pulmonary
Category(s):
Therapeutics & Vaccines
Device for MRI scanner intra-bore disinfection
Magnetic field-safe device for rapid disinfection of MRI bore and other types of scanners (CT, PET, PET-MR, SPECT) that is effective against COVID19, MRSA and other pathogens.</rss.brief Problem: With the advent of
COVID-19
, renewed emphasis has been placed on disinfecting surfaces in the medical environment. Disinfecting the MRI scanner bore...
Published:
6/23/2020
Inventor(s):
Norman Butler
,
James Pilla
,
Terence Gade
,
Gabor Mizsei
Keywords(s):
COVID-19
,
Infectious Disease
Category(s):
Medical Devices
,
Hardware & Circuits & Sensors
Protein drugs encapsulated in plant cells as low-cost prevention and treatment of lung injury in
COVID-19
patients
Use of functional recombinant ACE2 and Angiotensin-(1-7) proteins to improve the clinical course of patients with symptomatic
COVID-19
infection. Problem: COVID-19 is associated with high rates of respiratory failure, cardiac injury and death. Patients suffering from COVID-19 generally present with reduced expression of angiotensin converting enzyme...
Published:
6/2/2020
Inventor(s):
Henry Daniell
Keywords(s):
COVID-19
Category(s):
Therapeutics & Vaccines
Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy. Problem: Chimeric antigen receptor (CAR)...
Published:
5/4/2020
Inventor(s):
Margaret Billingsley
,
Carl June
,
Nathan Singh
,
Michael Mitchell
Keywords(s):
Bioengineering
,
COVID-19
,
Drug Delivery
,
Immunology
,
Immunotherapy
Category(s):
Therapeutics & Vaccines
Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo. Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant...
Published:
5/4/2020
Inventor(s):
Michael Mitchell
,
Rui Zhang
,
Roman Spektor
Keywords(s):
Bioengineering
,
COVID-19
Category(s):
Chemical Processes and Synthesis
,
Research Tools & Reagents
,
Therapeutics & Vaccines
Improving drug delivery using red blood cell hitchhiking
Problem: A major challenge in drug delivery is ensuring that the drug reaches the target organ at a concentration sufficient to treat the disease. This is particularly problematic for acute illnesses of the vasculature, such as acute respiratory distress syndrome (ARDS), ischemic stroke, and myocardial infarction. In these diseases, patients are often...
Published:
2/13/2020
Inventor(s):
Jacob Brenner
,
Vladimir Muzykantov
Keywords(s):
COVID-19
Category(s):
Therapeutics & Vaccines
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