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Search Results - covid-19
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Targeted Drug Delivery Using Red-Blood Cells for Transport
Platform technology for targeted drug delivery using red blood cells for transport.ProblemDrug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood cell.SolutionA...
Published: 6/23/2020
|
Inventor(s):
Laura Ferguson
,
Elizabeth Hood
,
Carlos Villa
,
Jacob Brenner
,
Vladimir Muzykantov
Keywords(s):
Acute Lung Injury
,
Cardiovascular
,
COVID-19
,
Drug Delivery
,
Nanotechnology
,
Respiratory
Category(s):
Therapeutics & Vaccines
Device for MRI Scanner Intra-Bore Disinfection
Magnetic field-safe device for rapid disinfection of MRI bore and other types of scanners (CT, PET, PET-MR, SPECT) that is effective against COVID19, MRSA and other pathogens. TechnologyProblemWith the advent of
Covid-19
, renewed emphasis has been placed on disinfecting surfaces in the medical environment. Disinfecting the MRI scanner bore is of particular...
Published: 6/23/2020
|
Inventor(s):
Norman Butler
,
James Pilla
,
Terence Gade
,
Gabor Mizsei
Keywords(s):
Antibacterial
,
Antifungal
,
Antiviral
,
COVID-19
Category(s):
Medical Devices
,
Hardware & Circuits & Sensors
Protein drugs encapsulated in plant cells as low-cost prevention and treatment of lung injury in
COVID-19
patients
Use of functional recombinant ACE2 and Angiotensin-(1-7) proteins to improve the clinical course of patients with symptomatic
COVID-19
infection. Problem: COVID-19 is associated with high rates of respiratory failure, cardiac injury and death. Patients suffering from COVID-19 generally present with reduced expression of angiotensin converting enzyme...
Published: 6/2/2020
|
Inventor(s):
Henry Daniell
Keywords(s):
COVID-19
Category(s):
Therapeutics & Vaccines
Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...
Published: 5/4/2020
|
Inventor(s):
Margaret Billingsley
,
Carl June
,
Nathan Singh
,
Michael Mitchell
Keywords(s):
Bioengineering
,
COVID-19
,
Drug Delivery
,
Immunology
,
Immunotherapy
Category(s):
Therapeutics & Vaccines
Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo.Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant progress...
Published: 5/4/2020
|
Inventor(s):
Michael Mitchell
,
Rui Zhang
,
Roman Spektor
Keywords(s):
Bioengineering
,
COVID-19
Category(s):
Chemical Processes and Synthesis
,
Research Tools & Reagents
,
Therapeutics & Vaccines
Improving drug delivery using red blood cell hitchhiking
Problem: A major challenge in drug delivery is ensuring that the drug reaches the target organ at a concentration sufficient to treat the disease. This is particularly problematic for acute illnesses of the vasculature, such as acute respiratory distress syndrome (ARDS), ischemic stroke, and myocardial infarction. In these diseases, patients are often...
Published: 2/13/2020
|
Inventor(s):
Jacob Brenner
,
Vladimir Muzykantov
Keywords(s):
COVID-19
Category(s):
Therapeutics & Vaccines
Repurposing of FDA-approved HER-inhibiting therapies for acute lung injury treatment
Mitigating ventilator-induced lung injury and acute respiratory distress syndrome through HER2/HER3 signaling pathway Problem: Acute lung injury, such as that induced by long-term treatment with a mechanical ventilator, and acute respiratory distress syndrome (ARDS) affects 190,000 patients per year in the United States, with associated mortality...
Published: 1/31/2020
|
Inventor(s):
Susan Margulies
Keywords(s):
COVID-19
Category(s):
Therapeutics & Vaccines
MicroRNA Mimics for the Treatment of Pneumonia
miR302-mimic is a therapeutic compound that accelerates regeneration of alveolar epithelial cells for treatment of bacterial pneumonia. Unlike standard treatment with antibiotics, which eliminate only the bacterial infection, this product would accelerate healing of the lungs to improve patient recovery time and could be given in conjunction with antibiotics. Technology...
Published: 4/30/2019
|
Inventor(s):
Hao Shen
Keywords(s):
COVID-19
Category(s):
Therapeutics & Vaccines
