Available Technologies

Browse Penn-owned technologies available for licensing.

HOME SEARCH RSS FEED

Search Results - drug delivery

3 Results Sort By:

Targeted drug delivery using red-blood cells for transport

Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood...

Published: 6/23/2020

Inventor(s):

Keywords(s):

Category(s):

Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering

A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...

Published: 5/4/2020

Inventor(s):

Keywords(s):

Category(s):

A drug delivery system tuned to the endogenous mechanical environment

Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....

Published: 1/28/2020

Inventor(s):

Keywords(s):

Category(s):