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Search Results - drug delivery

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Targeted drug delivery using red-blood cells for transport
Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red...
Published: 6/23/2020   |   Inventor(s): Laura Ferguson, Elizabeth Hood, Carlos Villa, Jacob Brenner, Vladimir Muzykantov
Keywords(s): Acute Lung Injury, Cardiovascular, COVID-19, Drug Delivery, Nanotechnology, Respiratory
Category(s): Therapeutics & Vaccines
Targeted, efficient, and safe intracellular drug delivery via nanocarriers
Cytosolic drug delivery using DNA-based nanocarriers coated with cell-targeted antibodies. Problem: The ability to deliver drugs intracellularly is critical for the treatment of diseases caused by aberrant processes within the cell. However, current drug delivery methods are ineffective at reaching the cell interior beyond the membranes of the endocytic...
Published: 5/20/2020   |   Inventor(s): Vladimir Muzykantov, Silvia Muro-Galindo
Keywords(s): Drug Delivery
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...
Published: 5/4/2020   |   Inventor(s): Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s): Therapeutics & Vaccines
A drug delivery system tuned to the endogenous mechanical environment
Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....
Published: 1/28/2020   |   Inventor(s): Robert Mauck, George Dodge, Daeyeon Lee
Keywords(s): Drug Delivery
Category(s): Therapeutics & Vaccines