A steerable needle system enables controllable sharp turns and complex tissue paths using a buckling shaft, orientable steering head, and transmission-driven steering.
Conjugating anti-T cell targeting domains onto anti-tumor autoantibodies to convert them into highly specific T cell-redirecting antibodies capable of increasing immune cell recruitment to tumor tissue.
A biocompatible hydrogel releases matrix metalloproteinase inhibitors when exposed to elevated protease activity in diseased tissue.
An all-aqueous microcapsule platform forms complexation films around cargo for biocompatible encapsulation without an oil phase.
A dual mRNA-LNP vaccine encoding Leishmania PEPCK and IL-12 to promote durable dermal-resident memory T cell responses.
Targeted delivery of an anti-inflammatory cytokine to prevent heart failure after myocardial infarction.
Pervious polymersomes encapsulate antioxidant agents while allowing reactive oxygen species to enter through diblock copolymer-defined channels.
A microfluidic chip that models blood-brain barrier biology using brain vascular and supporting cells, with optional neural progenitors and controlled agent exposure and mechanical stretching capabilities.
Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method.
Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies