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Search Results - drug+delivery

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Durable and targeted nanoparticle treatment for osteoarthritis

An osteoarthritis treatment comprised of TGFa nanoparticles that penetrate cartilage and persist in the joint. Problem: Osteoarthritis (OA), a degenerative joint disease, is the most common form of arthritis, with over 32 million adults affected in the US alone. Despite its prevalence and debilitating nature, no cure or disease-modifying treatment...

Published: 2/26/2021

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Targeted drug delivery using red-blood cells for transport

Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood...

Published: 6/23/2020

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Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering

A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy. Problem: Chimeric antigen receptor (CAR)...

Published: 5/4/2020

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