Enzymes that degrade mannose to prevent the formation of bacterial-fungal biofilms, which cause dental cavities Problem: Dental cavities are among the most common oral diseases among children and adults in the United States, with treatments for this condition exceeding $81 billion annually. Dental cavities occur when the bacteria Streptococcus mutans...

Dental implant that inhibits plaque accumulation and gingival tissue inflammation by photobiomodulation therapy delivered by embedded light-emitting diodes (LEDs) powered by electricity generated from the patient’s own oral motion. Problem: More than half of adults will lose one or more teeth in their lifetime. When a patient loses a tooth the...

Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...

rss.brief>A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time...

A COVID-19 diagnostic approach, utilizing a SARS-CoV-2 binding biosensor, that allows for real-time virus detection, without the need for sample processing, ultimately leading to population-level surveillance, outbreak tracking, reduced healthcare costs, improved treatment outcomes, and saved lives. Problem: SARS-CoV-2, the virus that causes COVID-19,...

A mixture has been identified that can rapidly deactivate SARS-CoV-2 and similar viruses for use during dental office procedures to prevent viral transmission. Problem: During routine dental procedures, aerosolized droplets containing water, a patient’s saliva and blood, microorganisms and other debris are produced as a result of commonly used...

Magnetic field-safe device for rapid disinfection of MRI bore and other types of scanners (CT, PET, PET-MR, SPECT) that is effective against COVID19, MRSA and other pathogens.</rss.brief Problem: With the advent of COVID-19, renewed emphasis has been placed on disinfecting surfaces in the medical environment. Disinfecting the MRI scanner bore...