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Search Results - michael mitchell

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Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...
Published: 5/4/2020   |   Inventor(s): Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s): Therapeutics & Vaccines
Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo.Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant progress...
Published: 5/4/2020   |   Inventor(s): Michael Mitchell, Rui Zhang, Roman Spektor
Keywords(s): Bioengineering, COVID-19
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines