Available Technologies

Browse Penn-owned technologies available for licensing.


Search Results - oncology

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Novel Inhibitors of Ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been suggested...
Published: 10/16/2020   |   Inventor(s): Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s): Antibody, Autoimmune, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Therapeutics & Vaccines
Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue
A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...
Published: 10/5/2020   |   Inventor(s): Deeksha Saxena, Jay Dorsey, Gary Kao, Donald O'rourke, Maclean Nasrallah
Keywords(s): Cell Therapy, Central Nervous System (CNS), Immunoncology, Oncology
Category(s): Chemical Processes and Synthesis, Diagnostics, Research Tools & Reagents
Novel AKR1C3 inhibitors in cancer
Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Technology Overview: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward...
Published: 9/29/2020   |   Inventor(s): Trevor Penning
Keywords(s): Gynecology, Men's Health, Oncology
Category(s): Therapeutics & Vaccines
Novel uses of androgen receptor inhibitors in cancer
Problem: For many cancer types, women have lower incidence and better outcomes than men. The role of sex steroid hormones, such as estrogen and testosterone, has been studied in reproductive organ cancers such as prostate and breast cancer, but not in other non-androgen (AR)-driven cancers. Recent studies have shown that testosterone promotes cancer...
Published: 4/28/2020   |   Inventor(s): Todd Ridky, Cristina Aguirre Portol├ęs, Christopher Natale
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines
Therapeutic targets for T-cell lymphomas and other types of cancer
Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....
Published: 3/20/2020   |   Inventor(s): Mariusz Wasik
Keywords(s): Immunology, Oncology
Category(s): Therapeutics & Vaccines
Novel Choline Kinase inhibitors for cancer imaging and therapy
Novel compounds allowing for optical detection and targeting of Choline Kinases for cancer treatment. Problem: Choline Kinase (ChoK) deregulation is associated with oncogenesis and tumor progression in a number of human cancers, including glioblastoma, breast, and lung cancers. In breast cancer, elevated ChoK activity is correlated with histological...
Published: 3/19/2020   |   Inventor(s): Edward Delikatny
Keywords(s): Oncology
Category(s): Diagnostics, Therapeutics & Vaccines, Imaging
Diagnosis and treatment of prostate cancer using a prostate cancer antibody
Monoclonal antibody and immunotherapy use in prostate cancer Technology Overview: Both androgen dependent and independent prostatic carcinomas have a high potential to metastasize. Unfortunately, the overall 5-year survival rate for metastatic prostate cancer is only 34%. Dr. Greene and his collaborators at the University of Pennsylvania have...
Published: 3/16/2020   |   Inventor(s): Mark Greene
Keywords(s): Oncology
Category(s): Diagnostics, Therapeutics & Vaccines
Her2/Neu Inhibitors for Cancer Therapy and Molecular Imaging
Cancer affects approximately 10 million people globally, with breast and lung cancer accounting for 25% of cancer incidences. Assuming over expression of Her2 is responsible for 25% of the breast cancer and lung cancer, and then the estimated market is about one million. The estimated price of Lapatinib, a small molecule tyrosine kinase inhibitor,...
Published: 3/16/2020   |   Inventor(s): Mark Greene
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines, Imaging
Universal cancer vaccine targeting tumor vasculature
A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis Technology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth....
Published: 3/16/2020   |   Inventor(s): George Coukos
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines
Phorboxazole compounds as potent anti-tumor agents
Problem: Phorboxazoles are naturally occurring compounds that have been isolated from the marine sponge Phorbas, endemic to the western coast of Australia. Previous screens of phorboxazoles against the National Cancer Institute human cell line panel indicated the most potent cytotoxicity assayed. While the mechanism of action in vivo is unknown,...
Published: 3/5/2020   |   Inventor(s): Amos Smith
Keywords(s): Oncology
Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines
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