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Scanner independent method for medical image standardization

A computer algorithm to standardize medical images acquired using positron emission tomography. Problem: Positron emission tomography (PET) is a commonly utilized imaging modality used for body-wide assessments of a variety of diseases, including cancer. Measurements derived from PET images are used to make diagnostic, staging, and treatment decisions...

Published: 11/2/2020

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Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Published: 10/16/2020

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Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue

A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...

Published: 10/5/2020

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Novel AKR1C3 inhibitors in cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Technology Overview: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward...

Published: 9/29/2020

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Novel uses of androgen receptor inhibitors in cancer

Repurposing of androgen receptors inhibitors for prostate cancer treatment to treat other cancer in males such as melanoma. Problem: For many cancer types, women have lower incidence and better outcomes than men. The role of sex steroid hormones, such as estrogen and testosterone, has been studied in reproductive organ cancers such as prostate and...

Published: 4/28/2020

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Therapeutic targets for T-cell lymphomas and other types of cancer

Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....

Published: 3/20/2020

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Novel Choline Kinase inhibitors for cancer imaging and therapy

Novel compounds allowing for optical detection and targeting of Choline Kinases for cancer treatment. Problem: Choline Kinase (ChoK) deregulation is associated with oncogenesis and tumor progression in a number of human cancers, including glioblastoma, breast, and lung cancers. In breast cancer, elevated ChoK activity is correlated with histological...

Published: 3/19/2020

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Diagnosis and treatment of prostate cancer using a prostate cancer antibody

Monoclonal antibody and immunotherapy use in prostate cancerTechnology Overview: Both androgen dependent and independent prostatic carcinomas have a high potential to metastasize. Unfortunately, the overall 5-year survival rate for metastatic prostate cancer is only 34%.Dr. Greene and his collaborators at the University of Pennsylvania have developed...

Published: 3/16/2020

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Her2/Neu inhibitors for cancer therapy and molecular imaging

Cancer affects approximately 10 million people globally, with breast and lung cancer accounting for 25% of cancer incidences. Assuming over expression of Her2 is responsible for 25% of the breast cancer and lung cancer, and then the estimated market is about one million. The estimated price of Lapatinib, a small molecule tyrosine kinase inhibitor,...

Published: 3/16/2020

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Universal cancer vaccine targeting tumor vasculature

A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesisTechnology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth. TEM1...

Published: 3/16/2020

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