Available Technologies

Browse Penn-owned technologies available for licensing.

Search Results - oncology

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Neuroprotection in TBI/Concussion via Dietary Supplement

A dietary supplement that protects brain cells from the effects of TBI and concussion Problem: Traumatic brain injury (TBI) is a major cause of death and disability. Mild TBIs (such as concussion) are particularly common for athletes and warfighters and can produce disabilities without immediate brain cell death. This may be due to damage to...

Published: 11/15/2021

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Tumor suppression by retinoic acid pathway inhibition

­ Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...

Published: 11/11/2021

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Adoptive T cell therapy for cancer using Mutant KRAS-specific T cell receptors for T cell engineering

We have isolated, cloned, and characterized multiple T cell receptors (TCRs) from human donors specific for common mutations in KRAS and restricted to highly prevalent HLA types. These TCRs, protected by a Penn provisional filing, are suitable for T cell engineering for the adoptive immunotherapy of cancer patients of select HLA types and tumors expressing...

Published: 10/9/2021

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Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...

Published: 11/5/2020

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Antibody discovery platform for CAR-T cell targeting and drug conjugation

Technology Overview: Screening platform for identification of potent and specific nanobodies for (i) directing CAR-T cells to cancer cells, (ii) drug conjugation, or (iii) tumor imaging or diagnosis. Identification of antibodies capable of mediating CAR-T killing is challenging due to several reasons. First, the antibody has to have certain affinity...

Published: 11/2/2020

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Scanner independent method for medical image standardization

A computer algorithm to standardize medical images acquired using positron emission tomography. Problem: Positron emission tomography (PET) is a commonly utilized imaging modality used for body-wide assessments of a variety of diseases, including cancer. Measurements derived from PET images are used to make diagnostic, staging, and treatment decisions...

Published: 11/2/2020

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Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue

A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...

Published: 10/5/2020

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Novel AKR1C3 inhibitors in cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Technology Overview: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward...

Published: 9/29/2020

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Novel uses of androgen receptor inhibitors in cancer

Repurposing of androgen receptors inhibitors for prostate cancer treatment to treat other cancer in males such as melanoma. Problem: For many cancer types, women have lower incidence and better outcomes than men. The role of sex steroid hormones, such as estrogen and testosterone, has been studied in reproductive organ cancers such as prostate and...

Published: 4/28/2020

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Therapeutic targets for T-cell lymphomas and other types of cancer

Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....

Published: 3/20/2020

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