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Search Results - oncology

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Novel uses of androgen receptor inhibitors in cancer
Problem: For many cancer types, women have lower incidence and better outcomes than men. The role of sex steroid hormones, such as estrogen and testosterone, has been studied in reproductive organ cancers such as prostate and breast cancer, but not in other non-androgen (AR)-driven cancers. Recent studies have shown that testosterone promotes cancer...
Published: 4/28/2020   |   Inventor(s): Todd Ridky, Cristina Aguirre Portol├ęs, Christopher Natale
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines
Therapeutic targets for T-cell lymphomas and other types of cancer
Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....
Published: 3/20/2020   |   Inventor(s): Mariusz Wasik
Keywords(s): Immunology, Oncology
Category(s): Therapeutics & Vaccines
Novel Choline Kinase inhibitors for cancer imaging and therapy
Novel compounds allowing for optical detection and targeting of Choline Kinases for cancer treatment. Problem: Choline Kinase (ChoK) deregulation is associated with oncogenesis and tumor progression in a number of human cancers, including glioblastoma, breast, and lung cancers. In breast cancer, elevated ChoK activity is correlated with histological...
Published: 3/19/2020   |   Inventor(s): Edward Delikatny
Keywords(s): Oncology
Category(s): Diagnostics, Therapeutics & Vaccines, Imaging
Diagnosis and treatment of prostate cancer using a prostate cancer antibody
Monoclonal antibody and immunotherapy use in prostate cancer Technology Overview: Both androgen dependent and independent prostatic carcinomas have a high potential to metastasize. Unfortunately, the overall 5-year survival rate for metastatic prostate cancer is only 34%. Dr. Greene and his collaborators at the University of Pennsylvania have...
Published: 3/16/2020   |   Inventor(s): Mark Greene
Keywords(s): Oncology
Category(s): Diagnostics, Therapeutics & Vaccines
Her2/Neu Inhibitors for Cancer Therapy and Molecular Imaging
Cancer affects approximately 10 million people globally, with breast and lung cancer accounting for 25% of cancer incidences. Assuming over expression of Her2 is responsible for 25% of the breast cancer and lung cancer, and then the estimated market is about one million. The estimated price of Lapatinib, a small molecule tyrosine kinase inhibitor,...
Published: 3/16/2020   |   Inventor(s): Mark Greene
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines, Imaging
Universal cancer vaccine targeting tumor vasculature
A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis Technology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth....
Published: 3/16/2020   |   Inventor(s): George Coukos
Keywords(s): Oncology, Vaccine
Category(s): Therapeutics & Vaccines
Phorboxazole compounds as potent anti-tumor agents
Problem: Phorboxazoles are naturally occurring compounds that have been isolated from the marine sponge Phorbas, endemic to the western coast of Australia. Previous screens of phorboxazoles against the National Cancer Institute human cell line panel indicated the most potent cytotoxicity assayed. While the mechanism of action in vivo is unknown,...
Published: 3/5/2020   |   Inventor(s): Amos Smith
Keywords(s): Oncology
Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines
Critical role of a kinase in breast cancer pathogenesis for use in diagnosis, therapy, and prognosis
SNF1-related serine/threonine kinase was found to play a critical role in the pathogenesis of breast cancers and is a potential diagnostic, prognostic, and therapeutic target. Problem: Various studies have shown that estradiol and progesterone play a critical role in the development of breast cancer. Moreover, aberrant expression or mutations of...
Published: 3/4/2020   |   Inventor(s): Lewis Chodosh
Keywords(s): Oncology
Category(s): Therapeutics & Vaccines, Diagnostics
Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells
The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...
Published: 1/29/2020   |   Inventor(s): Daniel Powell
Keywords(s): Antibody, Autoimmune, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Therapeutics & Vaccines
Monoclonal antibody to CXCR6
CXCR6 is a chemokine receptor expressed by leukocytes and other cells, and is believed to play a role in cancer metastasis, gut mucosal integrity, autoimmunity, diabetes and other inflammatory disorders. It is also used by SIV as a co-receptor for target cell entry. Technology Overview: Current commercially available monoclonal antibodies that...
Published: 1/28/2020   |   Inventor(s): Ronald Collman
Keywords(s): Antibody, Autoimmune, Oncology
Category(s): Research Tools & Reagents
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