rss.brief>A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time...

Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red blood...

A treatment for asthma where diacylglycerol kinase zeta is inhibited to target both inflammatory mediators and non-immune effectors linked to asthmatic responses. Problem: Asthma is a respiratory disease triggered by inflammatory mediators from T helper 2 (Th2) cells and non-immune effectors, such as smooth muscle shortening, which causes airway...

Reagents for improved DNA lipofection, depot anti-inflammation, and/or topical antimicrobial therapyTechnology Overview: Researchers in the Diamond Lab have developed a versatile new class of pharmacologically-active molecules with multiple applications. These molecules deliver plasmids (pDNA), adenovirus (AdV), and adeno-associated virus (AAV) to cultured...