Search Results - technology+classifications+%3e+vaccines

Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025

Peptides For Solid Cancer Tumor Immunotherapy Treatment

Short, multivalent peptide antagonists to block macrophage immune-receptor SIRPα, promoting cancer cell phagocytosis.

Published: 9/17/2025

Inventor(s):

Dennis Discher, AbdelAziz Jalil

Keywords(s):

Cell Therapy, Immunology, Oncology

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Methods and Sequences for mRNA and Other HIV Vaccine Development

Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine.

Published: 8/1/2025

Inventor(s):

George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman

Keywords(s):

Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)

Category(s):

Technology Classifications > Vaccines

Lipid Nanoparticles That Specifically Target The Lungs

Lung-targeting lipid nanoparticles allowing organ specific mRNA delivery for gene therapy applications.

Published: 11/26/2025

Inventor(s):

Michael Mitchell, Lulu Xue

Keywords(s):

Bioengineering, COVID-19, Gene Therapy, Infectious Disease, Pulmonary

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers

A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design.

Published: 9/12/2025

Inventor(s):

Virgil Percec, Drew Weissman, Juncheng (Luke) Lu, Elena Atochina-Vasserman, Devendra Maurya, Dipankar Sahoo

Keywords(s):

Drug Delivery, Platform Technology

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Vaccines

Universal cancer vaccine targeting tumor vasculature

A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis

Published: 3/19/2025

Inventor(s):

Andrea Facciabene, George Coukos

Keywords(s):

Oncology

Category(s):

Technology Classifications > Vaccines

Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines

Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation.