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Noninvasive cellular-scale observation of the structure of human photoreceptor cells is made possible through the use of adaptive optics (AO) enhanced ophthalmoscopes, but establishing noninvasive objective measures of photoreceptor function on a similar scale has been more difficult.
The inventors have developed a technique to assess the intrinsic function of individual photoreceptor cells using AO enhanced ophthalmoscope images acquired with near-infrared light. The images have high spatial resolution (single cell level) with low signal-to-noise ratio and could be easily incorporated into, and improve upon, existing AO enhanced ophthalmoscopes using infrared illumination.
Bottom: Preliminary results demonstrate that the Reflectance response can be used to measure non-functioning photoreceptors in those suffering retinopathies.