Browse Penn-owned technologies available for licensing.
Novel derivatives of 2,2’-diazaxanthylidine, with desirable properties for live cell imaging, were generated after photolysis and N-alkylation. Both the excitation and emission wavelengths are tunable, so different parts of the light spectrum can be exploited. Single cells can be easily activated and tracked, in addition to sequentially activated. Both mitochondria and lysosome stains have shown excellent specificity, reduced cytotoxicity, and greater protection against photobleaching compared to commercially available compounds.