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The increased level of GDF15 is also seen after a cancer therapy that often associates with nausea and emesis. It was only in 2017 when a receptor responsible for mediating the anorectic actions of GDF15 was identified. Hence, the hormone and its receptor are promising therapeutic targets for the treatment of disorders such as obesity, anorexia, and nausea associated with chemotherapy. Nausea from chemotherapy and morning sickness is difficult to manage and can be extremely debilitating and compromise individual quality of life.
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