Browse Penn-owned technologies available for licensing.
This technology is a simple, inexpensive, ultra-sensitive, and portable platinum nanoparticle-initiated bubbling digital assay (PNDA) platform for POC tests. A microfluidic array is decorated with antibodies for the target biomarker in close proximity to platinum nanoparticles, which catalyze the generation of oxygen microbubbles. The digital assay platform uses this “express bubbling” to transform and amplify the signal, thus enabling the detection of single molecules.
A widely available handheld microscope (or smart phone accessory) can be used to perform a readout from the PNDA Chip. The PNDA technology can be incorporated into a lateral flow assay (LFA) to provide a quantitative distance-based test readout. The entire immunoassay process can be integrated on to the LFA to process a single drop of sample in one step.