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In a collaboration between the University of Pennsylvania and Children's Hospital of Philadelphia, Dr. Vitale and Dr. Gonzalez-Alegre have developed an intracerebral drug delivery system that consists of three flexible, retractable silicone microcannulas housed within a single central catheter. This device delivers AAV to the full putamen through a single trajectory with double the infusion rate. This reduces the number of injections and minimizes surgical time.
The flexible silicone microcannulas minimize acute trauma and bleeding compared with conventional metal cannulas. The technology is expected to be compatible with treatment of other brain regions using any fluid-based drug delivery system, such as chemotherapeutic agents for glioblastoma.