Browse Penn-owned technologies available for licensing.
Electrophysiological recordings provide high temporal, but limited spatial resolution, due to the dense 3D architecture and geometrical inaccessibility of the brain.
An approach that integrates the advantages of both techniques could provide new insights into functions of neural circuits.
Transparent graphene electrodes can simultaneously record neural activity during calcium imaging with confocal or multi-phone microscopy without any laser-induced artifacts in the recordings.
Combination of both techniques has shown temporal and spatial characteristics of high frequency bursting activity and synaptic potentials in hippocampal slices with high precision.