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Various mouse strains and embryonic stem cell lines useful in studying Musashi 1 and/or 2 signaling
The mammalian Musashi (Msi) protein family consists of two members, Musashi 1 (Msi1) and Musashi 2 (Msi2), which are RNA binding proteins that have been shown to regulate stem cell self-renewal and tumorigenesis in numerous tissues. While the initial in vitro studies have laid the groundwork for understanding the molecular function of Msi proteins, it has been a challenge to study the role of this protein family in vivo, due to functional redundancy between Msi1 and Msi2 and embryonic lethality of Msi1-/-/Msi2-/- double knockout mice (unpublished).
Research in the laboratory of Dr. Chris Lengner has resulted in the development of multiple tools for the in vivo investigation of Msi family protein function. These tools enable spatio-temporal control of Msi1 and/or Msi2 gain and loss of function:
Chris Lengner, Lengner Laboratory
Docket # 14-7039, 14-7040, 14-7041 & 14-7042