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Critical role of a kinase in breast cancer pathogenesis for use in diagnosis, therapy, and prognosis

SNF1-related serine/threonine kinase was found to play a critical role in the pathogenesis of breast cancers and is a potential diagnostic, prognostic, and therapeutic target.

Problem: 

Various studies have shown that estradiol and progesterone play a critical role in the development of breast cancer. Moreover, aberrant expression or mutations of protein kinases have been linked to the pathogenesis of cancer in humans. The identification of a protein or small molecule that provides a molecular target in this pathway would provide significant diagnostic and therapeutic benefit to numerous cancer patients.

Solution: 

This invention relates to the discovery of a SNF1-related serine/threonine kinase and its nucleotide sequence, Hormonally Up-regulated, Neu-Tumor-Associated Kinase (HUNK). HUNK is markedly down regulated in a variety of human breast cancers and provides a useful molecular target for diagnosis, prognosis, and therapy.

Advantages: 

  • Use to diagnose ductal and lobular carcinomas of the breast
  • Use to screen for a HUNK agonist or antagonist
  • Use HUNK or HUNK nucleotide sequence for diagnosis and prognosis of disease
  • Use of inverse correlation of HUNK expression and tumor grade for ovarian cancer prognosis  

Stage of Development: 

In-vivo murine data

Intellectual Property: 

  • USSN 7,119,185
  • USSN 7,368,113

Reference Media:

Desired Partnerships: 

License
Patent Information:

Inventors:

Docket # M2335

For Information, Contact:

Linara Axanova Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu

Keywords