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SNF1-related serine/threonine kinase was found to play a critical role in the pathogenesis of breast cancers and is a potential diagnostic, prognostic, and therapeutic target.
Various studies have shown that estradiol and progesterone play a critical role in the development of breast cancer. Moreover, aberrant expression or mutations of protein kinases have been linked to the pathogenesis of cancer in humans. The identification of a protein or small molecule that provides a molecular target in this pathway would provide significant diagnostic and therapeutic benefit to numerous cancer patients.
This invention relates to the discovery of a SNF1-related serine/threonine kinase and its nucleotide sequence, Hormonally Up-regulated, Neu-Tumor-Associated Kinase (HUNK). HUNK is markedly down regulated in a variety of human breast cancers and provides a useful molecular target for diagnosis, prognosis, and therapy.
Lewis Chodosh, MD, PhD, Department of Cancer Biology
Stage of Development:
In-vivo murine data
Docket # M2335