Innovation at Penn
Browse Penn-owned technologies available for licensing.
Critical role of a kinase in breast cancer pathogenesis for use in diagnosis, therapy, and prognosis
SNF1-related serine/threonine kinase was found to play a critical role in the pathogenesis of breast cancers and is a potential diagnostic, prognostic, and therapeutic target.
Various studies have shown that estradiol and progesterone play a critical role in the development of breast cancer. Moreover, aberrant expression or mutations of protein kinases have been linked to the pathogenesis of cancer in humans. The identification of a protein or small molecule that provides a molecular target in this pathway would provide significant diagnostic and therapeutic benefit to numerous cancer patients.
This invention relates to the discovery of a SNF1-related serine/threonine kinase and its nucleotide sequence, Hormonally Up-regulated, Neu-Tumor-Associated Kinase (HUNK). HUNK is markedly down regulated in a variety of human breast cancers and provides a useful molecular target for diagnosis, prognosis, and therapy.
Use to diagnose ductal and lobular carcinomas of the breast
Use to screen for a HUNK agonist or antagonist
Use HUNK or HUNK nucleotide sequence for diagnosis and prognosis of disease
Use of inverse correlation of HUNK expression and tumor grade for ovarian cancer prognosis
Stage of Development:
In-vivo murine data
Yeh et al. Proc Natl Acad Sci, 2013, 110(15) - 6103-8
Yeh et al. J Clin Invest. 2011, 121(3) - 866-79
Gardner et al. Development. 2000, 127(20) - 4493-509
Docket # M2335
Bookmark this page
Download as PDF
For Information, Contact:
Associate Director, PSOM Licensing Group
University of Pennsylvania
Therapeutics & Vaccines
© 2021. All Rights Reserved. Powered by