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Traditional cell culture systems can unintentionally alter physiological properties of cells given the artificial 2D environment, while animal models are very costly and do not fully recapitulate human disorders or diseases, resulting in less efficient and expensive drug discovery. An improved high throughput model system is necessary that maintains fidelity to in vivo human physiological properties yet can be easily manipulated and tested.
(See image below for reference.) Overview of human 3D brain organoid generation and use in drug screening.