Problem:
Most current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine multi-scale architecture comprising brain function and do not interact with the brain’s capacity for self-reorganization and repair.
Solution:
An implantable electronic micro-sensor array on flexible substrate for the measurement and manipulation of neuronal activity with circuitry to adapt performance based on input patterns.
Advantages:
- Very high sensor density (20 nm spacing) improves signal quality and preserves space for effector circuits (electrical stimulators, optical emitters)
- Low temperature fabrication enables use of flexible polymer substrates to better adhere to curved tissue surfaces (brain, spinal cord, heart)
- Self-adaptive circuitry allows optimization of sensor and effector performance post-implantation
Applications:
- Diagnosis and treatment of Parkinson’s, Alzheimer’s, paralysis, cachexia, and cardiac arrhythmia/ischemia
- Implantable microarrays have been used to facilitate mental control of electronic devices by spinal injury patients
- Implantable cardiac defibrillators
Stage of Development:
- Prototype arrays have been produced with channel sizes of 60 nm and 20 nm
- Prototypes have been used to monitor electrical activity in porcine heart and rat cortex
Case ID:
V4966-tpNCS
Web Published:
3/11/2020
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