Available Technologies

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Measuring and manipulating neuronal signals using implantable electronic microsensor arrays


Most current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine multi-scale architecture comprising brain function and do not interact with the brain’s capacity for self-reorganization and repair. 



An implantable electronic micro-sensor array on flexible substrate for the measurement and manipulation of neuronal activity with circuitry to adapt performance based on input patterns. 



Brian Litt, MD, Department of Neurology



  • Very high sensor density (20 nm spacing) improves signal quality and preserves space for effector circuits (electrical stimulators, optical emitters)
  • Low temperature fabrication enables use of flexible polymer substrates to better adhere to curved tissue surfaces (brain, spinal cord, heart)
  • Self-adaptive circuitry allows optimization of sensor and effector performance post-implantation


  • Diagnosis and treatment of Parkinson’s, Alzheimer’s, paralysis, cachexia, and cardiac arrhythmia/ischemia
  • Implantable microarrays have been used to facilitate mental control of electronic devices by spinal injury patients
  • Implantable cardiac defibrillators  

Stage of Development: 

  • Prototype arrays have been produced with channel sizes of 60 nm and 20 nm
  • Prototypes have been used to monitor electrical activity in porcine heart and rat cortex

Intellectual Property: 

U.S. Patent 9,072,887


Reference Media: 

Bink, et al. 2011. Conf Proc IEEE Eng Med Biol Soc, 5400-3. doi: 10.1109/IEMBS.2011.6091335.  


Desired Partnerships: 

  • License
  • Collaboration

Docket # V4966