Available Technologies

Browse Penn-owned technologies available for licensing.


Carbon-based nanopipettes for single cell injection

Multiplexed, nanoscale electrochemical sensor for analyte delivery and detection


Technology Overview: 

The Bau Lab has developed carbon-based nanopipettes (CNPs) that allow for reliable single cell injection. These CNPs use an AC electrical impedance measurement to detect cell and nucleus penetration, which greatly improves upon standard pulled glass pipette injections. The small dimensions of the nanopipette enhance temporal resolution. Small volumes can be injected in a minimally invasive, controlled manner. Because carbon lining is conductive, CNPs can be used as accurate biosensors. 


This improved platform for single cell injection allows for automated, high-throughput methodology. This technology has been successfully demonstrated with fluorescent tRNA transfection of both the cytoplasm and nucleus of single cells.




Haim H. Bau, Professor of Mechanical Engineering and Applied Mechanics



  • Small dimensions, minimally invasive, does not break or clog easily
  • Compatible with biomaterials, micromanipulators, micropipette fittings, and amplifiers
  • Accurate injection into cytoplasm and/or nucleus
  • Mass producible



  • Single cell injection of probes, oligonucleotides, tracers, fluids, transfer of nucleic acid populations
  • Injection of very small amounts
  • Biosensors
  • Reliable, automated high-throughput platform for cell injection


Stage of Development: 

In vitro testing


Intellectual Property: 


Reference Media: 



Desired Partnerships: 

  • License
  • Co-development

Docket # V5030 and T4321


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Patent Information:
For Information, Contact:
Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
Haim Bau