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Researchers in the Diamond Lab have identified a new method of use for the cationic corticosteroid disubstituted dexamethasone spermine (D2S) as an anti-bacterial agent for both Gram-positive (e.g. MRSA) and Gram-negative (e.g. E. coli) organisms that can cause life-threatening situations, particularly in hospital-based infections. D2S has been demonstrated to exhibit antibacterial activity against clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa from cystic fibrosis sputa and biofilms. Furthermore, D2S enhances S. aureus susceptibility to antibiotics, including amoxicillin, tetracycline, and amikacin.