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For example, the gel may clog the delivery device if gelation is too fast, or the gel components may disperse at the injection site prior to gelation if the process is too slow.
Although these systems have many advantages, the same features that make them shear-thinning lead to materials that are not mechanically strong and that can disassemble rapidly. To overcome this mechanical weakness, the researchers have developed techniques that introduce a secondary crosslinking over minutes to hours after injection to permit stabilization and an increase in mechanics. This can occur through reactions such as a spontaneous crosslinking (via Michael addition) or a photocrosslinking process.